{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:17:39Z","timestamp":1788815859260,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T00:00:00Z","timestamp":1511740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>To compare dosimetric and treatment delivery parameter differences between volumetric\u2010modulated arc radiotherapy (VMAT<\/jats:styled-content>) and intensity\u2010modulated radiotherapy (IMRT<\/jats:styled-content>) for large volume retroperitoneal sarcomas (RPS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>Both VMAT<\/jats:styled-content> and IMRT<\/jats:styled-content> planning were performed on CT<\/jats:styled-content> datasets of 10 patients with RPS<\/jats:styled-content> who had been previously treated with preoperative radiotherapy. Plans were optimized to deliver \u226595% dose to the PTV<\/jats:styled-content> and were evaluated for conformity and homogeneity. Dose to the organs at risk (OAR<\/jats:styled-content>s) (kidney, liver, spinal cord, and bowel space), unspecified tissue, and dose evaluation volumes (DEV<\/jats:styled-content>s) at 1, 2, and 5 cm from PTV<\/jats:styled-content> were calculated and compared. Monitor units (MU<\/jats:styled-content>s) and treatment delivery times were recorded and compared between the two techniques. The deliverability of the large volume RPS VMAT<\/jats:styled-content> plans was verified by portal dosimetry on a Truebeam\u2122 linac.<\/jats:p><\/jats:sec>Results<\/jats:title>VMAT<\/jats:styled-content> and IMRT<\/jats:styled-content> plans were equivalent for PTV<\/jats:styled-content> coverage and homogeneity (P<\/jats:italic> > 0.05); however, VMAT<\/jats:styled-content> plans had slightly better conformity index, CI<\/jats:styled-content> (P<\/jats:italic> < 0.001). Doses to the OAR<\/jats:styled-content>s were not significantly different between VMAT<\/jats:styled-content> and IMRT<\/jats:styled-content> plans (P<\/jats:italic> > 0.05). Mean doses to the unspecified tissue as well as at 1, 2, and 5 cm DEV<\/jats:styled-content>s were lower with VMAT<\/jats:styled-content> compared with IMRT<\/jats:styled-content>, P<\/jats:italic> = 0.04 and P<\/jats:italic> < 0.01, respectively. MU<\/jats:styled-content>s and average beam\u2010on times were both significantly lower in the VMAT<\/jats:styled-content> vs IMRT<\/jats:styled-content> plans, P<\/jats:italic> < 0.001 and P<\/jats:italic> = 0.001, respectively. All VMAT<\/jats:styled-content> plans passed portal dosimetry delivery verification with an average gamma passing rate of 99.6 \u00b1 0.4%.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>VMAT<\/jats:styled-content> planning for large volume RPS<\/jats:styled-content> improved CI<\/jats:styled-content>, and achieved comparable OAR<\/jats:styled-content> sparing, as compared with IMRT<\/jats:styled-content>. As treatment delivery time was lower, the use of VMAT<\/jats:styled-content> for RPS<\/jats:styled-content> may translate into improved treatment delivery efficiency.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.12230","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T05:54:57Z","timestamp":1511762097000},"page":"276-281","source":"Crossref","is-referenced-by-count":6,"title":["Volumetric\u2010modulated arc therapy versus intensity\u2010modulated radiotherapy for large volume retroperitoneal sarcomas: A comparative analysis of dosimetric and treatment delivery parameters"],"prefix":"10.1002","volume":"19","author":[{"given":"Amandeep S.","family":"Taggar","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Toronto Toronto ON Canada"},{"name":"Odette Cancer Centre Sunnybrook Health Sciences Centre Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Graham","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Tom Baker Cancer Centre Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Kurien","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Tom Baker Cancer Centre Calgary AB Canada"},{"name":"Cumming School of Medicine Department of Oncology University of Calgary Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Gr\u00e4fe","sequence":"additional","affiliation":[{"name":"Department of Physics Ryerson University Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21264"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21761"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000086542.11899.38"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010715)92:2<359::AID-CNCR1331>3.0.CO;2-Y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(02)00283-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.8871"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199809000-00008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2001.1166"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20265"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.02.013"},{"key":"e_1_2_9_12_1","first-page":"39","article-title":"Intensity\u2010modulated radiation therapy vs. 3D conformal radiation therapy for squamous cell carcinoma of the anal canal","volume":"6","author":"Chuong MD","year":"2013","journal-title":"Gastrointest Cancer Res"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12203"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-17"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2010.06.011"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4922687"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.2818738"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-83"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.08.075"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00601-3"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.598248"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1120\/jacmp.v14i6.4286"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)01452-4"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.03.018"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00132-7"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.05.038"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"91\u2010015\u20100402\u2010z","DOI":"10.1186\/s13014-015-0402-z","article-title":"Which technique for radiation is most beneficial for patients with locally advanced cervical cancer? intensity modulated proton therapy versus intensity modulated photon treatment, helical tomotherapy and volumetric arc therapy for primary radiation \u2013 an intraindividual comparison","volume":"10","author":"Marnitz S","year":"2015","journal-title":"Radiat Oncol"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.06.013"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.12.020"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1120\/jacmp.v14i3.4269"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000372"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2014.03.003"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.02.047"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meddos.2010.05.001"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2363"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.138217"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.09.006"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.09.012"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.01.027"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.05.035"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e3180ca7cb1"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2012.06.014"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2009.08.011"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3326965"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-014-0219-1"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meddos.2013.01.006"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.08.004"}],"container-title":["Journal of Applied Clinical Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facm2.12230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.12230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acm2.12230","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.12230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T01:00:52Z","timestamp":1694394052000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1002\/acm2.12230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,27]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/acm2.12230"],"URL":"https:\/\/doi.org\/10.1002\/acm2.12230","archive":["Portico"],"relation":{},"ISSN":["1526-9914","1526-9914"],"issn-type":[{"value":"1526-9914","type":"print"},{"value":"1526-9914","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,27]]}}}