{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:15:26Z","timestamp":1786976126399,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61471226"],"award-info":[{"award-number":["61471226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2017BF005"],"award-info":[{"award-number":["ZR2017BF005"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Xerostomia induced by radiotherapy is a common toxicity for head and neck carcinoma patients. In this study, the deformable image registration of planning computed tomography (\n                    <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                    ) and weekly cone\u2010beam\n                    <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">CBCT<\/jats:styled-content>\n                    ) was used to override the Hounsfield unit value of\n                    <jats:styled-content style=\"fixed-case\">CBCT<\/jats:styled-content>\n                    , and the modified\n                    <jats:styled-content style=\"fixed-case\">CBCT<\/jats:styled-content>\n                    was introduced to estimate the radiation dose delivered during the course of treatment. Herein, the beams from each patient's treatment plan were applied to the modified\n                    <jats:styled-content style=\"fixed-case\">CBCT<\/jats:styled-content>\n                    to construct the weekly delivered dose. Then, weekly doses were summed together to obtain the accumulated dose. A total of 42 parotid glands (\n                    <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>\n                    s) of 21 nasopharyngeal carcinoma patients were analyzed. Doses delivered to the parotid glands significantly increased compared with the planning doses. V\n                    <jats:sub>20<\/jats:sub>\n                    , V\n                    <jats:sub>30<\/jats:sub>\n                    , V\n                    <jats:sub>40<\/jats:sub>\n                    , D\n                    <jats:sub>mean<\/jats:sub>\n                    , and D\n                    <jats:sub>50<\/jats:sub>\n                    increased by 11.3%, 28.6%, 44.4%, 9.5%, and 8.4% respectively. Of the 21 patients included in the study, eight developed xerostomia and the remaining 13 did not. Both planning and delivered\n                    <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>\n                    D\n                    <jats:sub>mean<\/jats:sub>\n                    for all patients exceeded tolerance (26 Gy). Among the 21 patients, the planning dose and delivered dose of D\n                    <jats:sub>mean<\/jats:sub>\n                    were 30.6 Gy and 33.6 Gy, respectively, for patients with xerostomia, and 26.3 Gy and 28.0 Gy, respectively, for patients without xerostomia. The D\n                    <jats:sub>50<\/jats:sub>\n                    of the planning and delivered dose for patients was below tolerance (30 Gy). The results demonstrated that the p\u2010value of V\n                    <jats:sub>20<\/jats:sub>\n                    , V\n                    <jats:sub>30<\/jats:sub>\n                    , D\n                    <jats:sub>50<\/jats:sub>\n                    , and D\n                    <jats:sub>mean<\/jats:sub>\n                    difference of the delivery dose between patients with xerostomia and patients without xerostomia was less than 0.05. However, for the planning dose, the significant dosimetric difference between the two groups only existed in D\n                    <jats:sub>50<\/jats:sub>\n                    and D\n                    <jats:sub>mean<\/jats:sub>\n                    . Xerostomia is closely related to V\n                    <jats:sub>20<\/jats:sub>\n                    , V\n                    <jats:sub>30<\/jats:sub>\n                    , D\n                    <jats:sub>50<\/jats:sub>\n                    , and D\n                    <jats:sub>mean<\/jats:sub>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/acm2.12327","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T08:08:28Z","timestamp":1523952508000},"page":"251-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Parotid gland radiation dose\u2010xerostomia relationships based on actual delivered dose for nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"19","author":[{"given":"Jingjiao","family":"Lou","sequence":"first","affiliation":[{"name":"Shandong Province Key Laboratory of Medical Physics and Image Processing Technology Institute of Biomedical Sciences School of Physics and Electronics Shandong Normal University No.88, Wenhua East Road Jinan 250014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Huang","sequence":"additional","affiliation":[{"name":"Shandong Province Key Laboratory of Medical Physics and Image Processing Technology Institute of Biomedical Sciences School of Physics and Electronics Shandong Normal University No.88, Wenhua East Road Jinan 250014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital Affiliated to Shandong University Shandong Academy of Medical Science No.440, Jiyan Road Jinan 250117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shandong Province Key Laboratory of Medical Physics and Image Processing Technology Institute of Biomedical Sciences School of Physics and Electronics Shandong Normal University No.88, Wenhua East Road Jinan 250014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhu","family":"Chen","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital Affiliated to Shandong University Shandong Academy of Medical Science No.440, Jiyan Road Jinan 250117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqiang","family":"Liang","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital Affiliated to Shandong University Shandong Academy of Medical Science No.440, Jiyan Road Jinan 250117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital Affiliated to Shandong University Shandong Academy of Medical Science No.440, Jiyan Road Jinan 250117 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