{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:11:00Z","timestamp":1791389460036,"version":"4.3.3"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this work was to compare dose distributions between two radiosurgery modalities, single\u2010isocenter volumetric modulated arc therapy (<jats:styled-content style=\"fixed-case\">VMAT<\/jats:styled-content>), and GammaKnife Perfexion (<jats:styled-content style=\"fixed-case\">GK<\/jats:styled-content>), in the treatment of a large number (\u22657) of brain metastases. Twelve patients with 103 brain metastases were analyzed. The median number of targets per patient was 8 (range: 7\u201314). <jats:styled-content style=\"fixed-case\">GK<\/jats:styled-content> plans were compared to noncoplanar <jats:styled-content style=\"fixed-case\">VMAT<\/jats:styled-content> plans using both 6\u2010<jats:styled-content style=\"fixed-case\">MV<\/jats:styled-content> flattening filter\u2010free (<jats:styled-content style=\"fixed-case\">FFF<\/jats:styled-content>) and 10\u2010<jats:styled-content style=\"fixed-case\">MV FFF<\/jats:styled-content> modes. Parameters analyzed included radiation therapy oncology group conformity index (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 12, 6, and 3\u00a0Gy isodose volumes (V12\u00a0Gy, V6\u00a0Gy, V3\u00a0Gy), mean and maximum hippocampal dose, and maximum skin dose. There were statistically significant differences in <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (2.5\u00a0\u00b1\u00a01.6 vs 1.6\u00a0\u00b1\u00a00.8 and 1.7\u00a0\u00b1\u00a00.9, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001), V12\u00a0Gy (2.8\u00a0\u00b1\u00a06.1\u00a0cc vs 3.0\u00a0\u00b1\u00a05.2\u00a0cc and 3.1\u00a0\u00b1\u00a05.4\u00a0cc, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.003, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001), and V3\u00a0Gy (323.0\u00a0\u00b1\u00a0294.8\u00a0cc vs, 880.1\u00a0\u00b1\u00a0369.1\u00a0cc and 937.9\u00a0\u00b1\u00a0 vs 361.9\u00a0cc, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.005, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.001) between <jats:styled-content style=\"fixed-case\">GK<\/jats:styled-content> versus both 6\u2010<jats:styled-content style=\"fixed-case\">MV FFF<\/jats:styled-content> and 10\u2010<jats:styled-content style=\"fixed-case\">MV FFF<\/jats:styled-content>. No significant differences existed for maximum hippocampal or skin doses. In conclusion, highly optimized <jats:styled-content style=\"fixed-case\">VMAT<\/jats:styled-content> produced improved conformity at the expense of a higher V12\u00a0Gy and V3\u00a0Gy volume when compared with highly optimized <jats:styled-content style=\"fixed-case\">GK<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/acm2.12471","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T04:43:53Z","timestamp":1538801033000},"page":"159-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["GammaKnife versus <scp>VMAT<\/scp> radiosurgery plan quality for many brain metastases"],"prefix":"10.1002","volume":"19","author":[{"given":"Peter S","family":"Potrebko","sequence":"first","affiliation":[{"name":"College of Medicine University of Central Florida Orlando FL USA"},{"name":"Department of Physics University of Central Florida Orlando FL USA"},{"name":"Department of Radiation Oncology Florida Hospital Orlando FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Keller","sequence":"additional","affiliation":[{"name":"College of Medicine University of Central Florida Orlando FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"All","sequence":"additional","affiliation":[{"name":"College of Medicine University of Central Florida Orlando FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Sejpal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Florida Hospital Orlando FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Pepe","sequence":"additional","affiliation":[{"name":"Department of Research Florida Hospital Orlando FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal","family":"Saigal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Florida Hospital Orlando FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shravan","family":"Kandula","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Florida Hospital Orlando FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F","family":"Sensakovic","sequence":"additional","affiliation":[{"name":"College of Medicine University of Central Florida Orlando FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Shridhar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Florida Hospital Orlando FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Poleszczuk","sequence":"additional","affiliation":[{"name":"Nalecz Institute of Biocybernetics and Biomedical Engineering Polish Academy of Sciences Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Biagioli","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Florida Hospital Orlando FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.05.023"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70061-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.46.9.797"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2011.12.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2016.00026"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000448"},{"key":"e_1_2_8_8_1","unstructured":"White Paper: Inverse Planning in Leksell GammaPlan10. 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