{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T03:08:12Z","timestamp":1715396892713},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004699","name":"Chung Shan Medical University Hospital","doi-asserted-by":"publisher","award":["CSH-2009-A-004"],"award-info":[{"award-number":["CSH-2009-A-004"]}],"id":[{"id":"10.13039\/501100004699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004319","name":"Shin Kong Wu Ho-Su Memorial Hospital","doi-asserted-by":"publisher","award":["SKH-8302-103-0602"],"award-info":[{"award-number":["SKH-8302-103-0602"]}],"id":[{"id":"10.13039\/501100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Although breast density is considered a strong risk factor of breast cancer, its quantitative assessment is difficult. To investigate a quantitative method of measuring breast density using dual\u2010energy mammographic imaging with central digital breast tomosynthesis in physically uniform and nonuniform phantoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>The dual\u2010energy imaging unit used a tungsten anode and silver filter with 30\u00a0kVp for high\u2010energy images and 20\u00a0kVp for low\u2010energy images. Uniform glandular\u2010equivalent phantoms were used to calibrate a dual\u2010energy based decomposition algorithm. The first study used uniform breast phantoms which ranged in thicknesses from 20 to 70\u00a0mm, in 10\u2010mm increments, and which provided 30%, 50%, and 70% of breast density. The second study used uniform phantoms ranging from 10% to 90% of breast density. The third study used non\u2010uniform phantoms (at an average density of 50%) with a thickness which ranged from 20 to 90\u00a0mm, in 10\u2010mm increments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The root mean square error of breast density measurements was 2.64\u20133.34% for the uniform, variable thickness phantoms, 4.17% for the uniform, variable density phantoms, and 4.49% for the nonuniform, variable thickness phantoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The dual\u2010energy technique could be used to measure breast density with a margin of error of\u00a0&lt;\u00a010% using digital breast tomosynthesis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.12618","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T12:04:46Z","timestamp":1558353886000},"page":"170-177","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantitative evaluation of breast density using a dual\u2010energy technique on a digital breast tomosynthesis system"],"prefix":"10.1002","volume":"20","author":[{"given":"Kun\u2010Mu","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Radiology Shin Kong Wu Ho\u2010Su Memorial Hospital Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da\u2010Ming","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Chung Shan Medical University Hospital Taichung City Taiwan"},{"name":"Department of Medical Imaging and Radiological Sciences Chung Shan Medical University Taichung City 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