{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:54:31Z","timestamp":1772816071665,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We report the first cervical cancer cases treated with interstitial electronic brachytherapy (eBT) at our hospital and compare them with plans made with high\u2010dose\u2010rate interstitial brachytherapy based on Ir192 (HDR\u2010BT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Eight patients with cervical cancer were treated with the Axxent eBT device (Xoft, Inc.). Planning was with magnetic resonance imaging and computed tomography following the recommendations of the EMBRACE protocol. The dosimetry parameters of organs at risk (OAR) were evaluated for the bladder, rectum, and sigmoid colon (D2cc, D1cc, and D0.1cc). In addition, the V150 and V200 of irradiated tissue were compared for both eBT and HDR\u2010BT. All patients received intensity\u2010modulated external beam radiation therapy with a regimen of 23 sessions of 2\u00a0Gy followed by four sessions of 7\u00a0Gy of eBT performed over 2\u00a0weeks (two sessions followed by another two sessions a week later) following the EMBRACE recommendations. Each of the eight patients was followed to assess acute toxicity associated with treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The doses reaching OAR for eBT plans were lower than for HDR\u2010BT plans. As for acute toxicity associated with eBT, very few cases of mucositis were detected. No cases of rectal toxicity and one case with grade 1 urinary toxicity were detected. The results at 1\u00a0month are equally good, and no relapses have occurred to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The first results of treatment with the Axxent eBT device are promising, as no recurrences have been observed and toxicity is very low. eBT is a good alternative for treating cervical cancer in centers without access to conventional HDR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.12657","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T07:44:30Z","timestamp":1560239070000},"page":"78-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Treatment of cervical cancer with electronic brachytherapy"],"prefix":"10.1002","volume":"20","author":[{"given":"Sergio","family":"Lozares-Cordero","sequence":"first","affiliation":[{"name":"Department of Physics and Radiation Protection Miguel Servet University Hospital Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"Font-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Physics and Radiation Protection Miguel Servet University Hospital Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almudena","family":"Gand\u00eda\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Physics and Radiation Protection Miguel Servet University Hospital Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anabela","family":"Miranda\u2010Burgos","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Miguel Servet University Hospital Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agustina","family":"M\u00e9ndez\u2010Villam\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Miguel Servet University Hospital Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Villa\u2010Gazulla","sequence":"additional","affiliation":[{"name":"Department of Physics and Radiation Protection Miguel Servet University Hospital Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Alba\u2010Escorihuela","sequence":"additional","affiliation":[{"name":"Department of Physics and Radiation Protection Miguel Servet University Hospital Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Jim\u00e9nez\u2010Puertas","sequence":"additional","affiliation":[{"name":"Department of Physics and Radiation Protection Miguel Servet University Hospital Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"Gonz\u00e1lez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Physics and Radiation Protection Fundaci\u00f3n IVO Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,11]]},"reference":[{"key":"e_1_2_8_2_1","series-title":"A guide to essential practice","author":"World Health Organization","year":"2014"},{"key":"e_1_2_8_3_1","unstructured":"National Comprehensive Cancer Network Inc. 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