{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T11:27:30Z","timestamp":1781954850624,"version":"3.54.5"},"reference-count":7,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Prior <jats:italic>in silico<\/jats:italic> simulations propose that Temporally Feathered Radiation Therapy (TFRT) may reduce toxicity related to head and neck radiation therapy. In this study we demonstrate a step\u2010by\u2010step guide to TFRT planning with modern treatment planning systems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One patient with oropharyngeal cancer planned for definitive radiation therapy using intensity\u2010modulated radiation therapy (IMRT) techniques was replanned using the TFRT technique. Five organs at risk (OAR) were identified to be feathered. A \u201cbase plan\u201d was first created based on desired planning target volumes (PTV) coverage, plan conformality, and OAR constraints. The base plan was then re\u2010optimized by modifying planning objectives, to generate five subplans. All beams from each subplan were imported onto one trial to create the composite TFRT plan. The composite TFRT plan was directly compared with the non\u2010TFRT IMRT plan. During plan assessment, the composite TFRT was first evaluated followed by each subplan to meet preset compliance criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The following organs were feathered: oral cavity, right submandibular gland, left submandibular gland, supraglottis, and OAR Pharynx. Prescription dose PTV coverage (&gt;95%) was met in each subplan and the composite TFRT plan. Expected small variations in dose were observed among the plans. The percent variation between the high fractional dose and average low fractional dose was 29%, 28%, 24%, 19%, and 10% for the oral cavity, right submandibular, left submandibular, supraglottis, and OAR pharynx nonoverlapping with the PTV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Temporally Feathered Radiation Therapy planning is possible with modern treatment planning systems. Modest dosimetric changes are observed with TFRT planning compared with non\u2010TFRT IMRT planning. We await the results of the current prospective trial to seeking to demonstrate the feasibility of TFRT in the modern clinical workflow (NCT03768856). Further studies will be required to demonstrate the potential benefit of TFRT over non\u2010TFRT IMRT Planning.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.12893","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T08:10:20Z","timestamp":1588925420000},"page":"209-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Technical Note: A step\u2010by\u2010step guide to Temporally Feathered Radiation Therapy planning for head and neck cancer"],"prefix":"10.1002","volume":"21","author":[{"given":"Shireen","family":"Parsai","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L. J.","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Winship Cancer Institute of Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C. L.","family":"Alfonso","sequence":"additional","affiliation":[{"name":"Braunschweig Integrated Centre of Systems Biology Hemholtz Centre of Infection Research Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Donaghue","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Majkszak","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Dorio","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifton D.","family":"Fuller","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Brock","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomo","family":"Koyfman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Woody","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob G.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.1876"},{"key":"e_1_2_8_3_1","unstructured":"AlfonsoJCL ParsaiS JoshiNet 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