{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:17:05Z","timestamp":1768889825935,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Planning target volume (PTV) has been used to account for variations in tissue, patient and beam position. In oropharyngeal cancers, an isotropic expanded PTV has been used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to design a new margin formula that would cover the space occupied by an oropharyngeal clinical target volume (CTV) with \u00b15\u2010degree rotation around the spine in order to reduce the pharyngeal constrictors overlap with PTV compared to an isotropic expanded PTV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated 20 volumetric\u2010modulated arc therapy (VMAT) plans. In order to perform an off\u2010axis rotation, a hypothetical point was placed through the center of the cervical spinal canal and the image was then rotated around the longitudinal axis \u00b15 degrees. This created a new set of CTVs that were combined to form the new rotational PTV. The overlap between the pharyngeal constrictor muscles (PCMs) and both PTVs was then evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The new rotational PTV causes reduction in the superior PCM overlap in the base of tongue (BOT) lesions compared to tonsillar lesion, 57.8% vs 25.8%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01, as well as middle PCM overlap, 73% vs 49%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04. Average percent change for PTV volume and overlap with the superior, middle, and inferior PCMs are as followed: \u221219%, \u221237%, \u221259.4%, and \u221245.2. The smallest isotropic expansion that covers the new rotational PTV was between 3 and 5mm with the average tumor center shift of 0.49\u00a0cm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This new rotational PTV causes significant reduction of the overlap volume between PCMs and PTVs in order to spare the PCMs compared to isotropic expanded PTV.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.13052","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T05:37:13Z","timestamp":1603172233000},"page":"172-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of designing a rotational planning target volume on sparing pharyngeal constrictor muscles in patients with oropharyngeal cancer"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5770-4768","authenticated-orcid":false,"given":"Mona","family":"Arbab","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huisi","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Dawson","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Langer","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.12.033"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semradonc.2003.10.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.ijrobp.2005.08.021","article-title":"The need for rotational margins in intensity\u2010modulated radiotherapy and a new method for planning target volume design","volume":"63","author":"Langer MP","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-007-1695-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1120\/jacmp.v12i3.3422"},{"key":"e_1_2_7_7_1","first-page":"95","article-title":"Computation of spatial displacements from geometric features","volume":"115","author":"Ravani B","year":"1993","journal-title":"J Mechan Des"},{"key":"e_1_2_7_8_1","first-page":"1073","article-title":"Computation of spatial displacements from redundant geometric features","volume":"116","author":"Ge Q","year":"1994","journal-title":"J Mechan Des"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.02.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.862593"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-011-0015-x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ijrobp.2016.07.011","article-title":"Head and neck margin reduction with adaptive radiation therapy: robustness of treatment plans against anatomy changes","volume":"96","author":"Kranen S","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.radonc.2016.01.019","article-title":"Beyond mean pharyngeal constrictor dose for beam path toxicity in non\u2010target swallowing muscles: dose\u2013volume correlates of chronic radiation\u2010associated dysphagia (RAD) after oropharyngeal intensity modulated radiotherapy","volume":"118","author":"Head","year":"2016","journal-title":"Radiother Oncol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23200"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.07.009"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.06.032"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2015.03.002"},{"key":"e_1_2_7_18_1","first-page":"3270","article-title":"Accurate positioning for head and neck cancer patients using 2D and 3D image guidance","volume":"12","author":"Kang H","year":"2010","journal-title":"J Appl Clin Med Phys"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4236\/ijmpcero.2013.24016","article-title":"The reproducibility of patient setup for head and neck cancers treated with image\u2010guided and intensity\u2010modulated radiation therapies using thermoplastic immobilization device","volume":"2","author":"Nakata A","year":"2013","journal-title":"Int J Med Phys Clin Eng Radiat Oncol"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00518-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.11.016"},{"key":"e_1_2_7_22_1","volume-title":"Matrices and Transformations","author":"Petrofrezzo AJ","year":"1978"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.05.015"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2020.38.15_suppl.6508"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.08.009"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02749-9"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jbiomech.2018.05.024","article-title":"Spinal constraint modulates head instantaneous center of rotation and dictates head angular motion","volume":"76","author":"Kuo C","year":"2018","journal-title":"J Biomech"},{"key":"e_1_2_7_28_1","unstructured":"Impact of patient rotational errors on target and critical structure dose in IMRT: A 3D simulation study. Journal of Physics: Conference Series;2013. IOP Publishing."},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.06.2456"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.05.004"}],"container-title":["Journal of Applied Clinical Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.13052","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acm2.13052","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.13052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T01:42:27Z","timestamp":1693878147000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1002\/acm2.13052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,19]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/acm2.13052"],"URL":"https:\/\/doi.org\/10.1002\/acm2.13052","archive":["Portico"],"relation":{},"ISSN":["1526-9914","1526-9914"],"issn-type":[{"value":"1526-9914","type":"print"},{"value":"1526-9914","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,19]]},"assertion":[{"value":"2020-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}