{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:42:28Z","timestamp":1788482548348,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Abdominal compression can minimize breathing motion in stereotactic radiotherapy, though it may impact the positioning of dose\u2010limiting normal tissues. This study quantified the reproducibility of abdominal normal tissues and respiratory motion with the use of an abdominal compression device using MR imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty healthy volunteers had repeat MR over 3\u00a0days under an abdominal compression plate device. Normal tissues were delineated on daily axial T2\u2010weighted MR and compared on days 2 and 3 relative to day 1, after adjusting for baseline shifts relative to bony anatomy. Inter\u2010fraction organ deformation was computed using deformable registration of axial T2 images. Deformation\u00a0&gt;\u00a05\u00a0mm was assumed to be clinically relevant. Inter\u2010fraction respiratory amplitude changes and intra\u2010fraction baseline drifts during imaging were quantified on daily orthogonal cine\u2010MR (70\u00a0s each), and changes\u00a0&gt;\u00a03\u00a0mm were assumed to be relevant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On axial MR, the mean inter\u2010fraction normal tissue deformation was\u00a0&gt;\u00a05\u00a0mm for all organs (range 5.1\u201313.4\u00a0mm). Inter\u2010fraction compression device misplacements\u00a0&gt;\u00a05\u00a0mm and changes in stomach volume\u00a0&gt;\u00a050% occurred at a rate of 93% and 38%, respectively, in one or more directions and were associated with larger adjacent organ deformation, in particular for the duodenum. On cine\u2010MR, inter\u2010fraction amplitude changes\u00a0&gt;\u00a03\u00a0mm on day 2 and 3 relative to day 1 occurred at a rate of\u00a0&lt;\u00a012.5% (mean superior\u2013inferior change was 1.6\u00a0mm). Intra\u2010fraction baseline drifts\u00a0&gt;\u00a03\u00a0mm during any cine\u2010MR acquisition occurred at a rate of 23% (mean superior\u2013inferior changes was 2.4\u00a0mm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Respiratory motion under abdominal compression is reproducible in most subjects within 3\u00a0mm. However, inter\u2010fraction deformations greater than 5\u00a0mm in normal tissues were common and larger than inter\u2010 and intra\u2010fraction respiratory changes. Deformations were driven mostly by variable stomach contents and device positioning. The magnitude of this motion may impact normal tissue dosimetry during stereotactic radiotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.13165","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T23:51:33Z","timestamp":1610754693000},"page":"90-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["MRI evaluation of normal tissue deformation and breathing motion under an abdominal compression device"],"prefix":"10.1002","volume":"22","author":[{"given":"Maureen","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre University Health Network University of Toronto 610 University Avenue Toronto ON M5G 2M9 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Simeonov","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre University Health Network University of Toronto 610 University Avenue Toronto ON M5G 2M9 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teo","family":"Stanescu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre University Health Network University of Toronto 610 University Avenue Toronto ON M5G 2M9 Canada"},{"name":"TECHNA Institute University Health Network 100 College Street Toronto ON M5G 1L5 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre University Health Network University of Toronto 610 University Avenue Toronto ON M5G 2M9 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy K.","family":"Brock","sequence":"additional","affiliation":[{"name":"Department of Imaging Physics The University of Texas MD Anderson Cancer Center Houston TX 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Velec","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Margaret Cancer Centre University Health Network University of Toronto 610 University Avenue Toronto ON M5G 2M9 Canada"},{"name":"TECHNA Institute University Health Network 100 College Street Toronto ON M5G 1L5 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