{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:12:44Z","timestamp":1783548764731,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>March 2021 will mark the eightieth anniversary of targeted radionuclide therapy, recognizing the first use of radioactive iodine to treat thyroid disease by Dr. Saul Hertz on March 31, 1941. The breakthrough of Dr. Hertz and collaborator physicist Arthur Roberts was made possible by rapid developments in the fields of physics and medicine in the early twentieth century. Although diseases of the thyroid gland had been described for centuries, the role of iodine in thyroid physiology had been elucidated only in the prior few decades. After the discovery of radioactivity by Henri Becquerel in 1897, rapid advancements in the field, including artificial production of radioactive isotopes, were made in the subsequent decades. Finally, the diagnostic and therapeutic use of radioactive iodine was based on the tracer principal that was developed by George de Hevesy. In the context of these advancements, Hertz was able to conceive the potential of using of radioactive iodine to treat thyroid diseases. Working with Dr. Roberts, he obtained the experimental data and implemented it in the clinical setting. Radioiodine therapy continues to be a mainstay of therapy for hyperthyroidism and thyroid cancer. However, Hertz struggled to gain recognition for his accomplishments and to continue his work and, with his early death in 1950, his contributions have often been overlooked until recently. The work of Hertz and others provided a foundation for the introduction of other radionuclide therapies and for the development of the concept of theranostics.<\/jats:p>","DOI":"10.1002\/acm2.13175","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T11:09:43Z","timestamp":1612609783000},"page":"4-10","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Celebrating eighty years of radionuclide therapy and the work of Saul Hertz"],"prefix":"10.1002","volume":"22","author":[{"given":"Frederic H.","family":"Fahey","sequence":"first","affiliation":[{"name":"Department of Radiology Boston Children\u2019s Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick D.","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Radiology Children\u2019s Hospital of Philadelphia University of Pennsylvania School of Medicine Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,3]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"15","article-title":"Saul Hertz, MD, and the birth of radionuclide therapy","volume":"4","author":"Fahey FH","year":"2017","journal-title":"Eur J Nucl Med Molecular Imag"},{"key":"e_1_2_11_3_1","first-page":"463","article-title":"Paracelsus on goiter and cretinism: a translation and discussion of \u201cDe Struma, Vulgo der Kropf\u201d","volume":"37","author":"Cranefield P","year":"1963","journal-title":"Bull Hist Med"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ed077p984"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1093\/jn\/138.11.2060","article-title":"Research on iodine deficiency and goiter in the 19th and early 20th centuries","volume":"138","author":"Zimmerman MB","year":"2008","journal-title":"J Nutrit"},{"key":"e_1_2_11_6_1","first-page":"515","article-title":"Clinical lectures delivered at the Meath Hospital during the session 1834\u20131835. 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