{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T01:10:06Z","timestamp":1744679406450,"version":"3.40.4"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dose escalation is key for improved outcomes in intermediate\u2010risk prostate cancer, including unfavorable intermediate\u2010risk (UIR) cases. This educational report is designed to provide information about our quality high\u2010dose <jats:sup>125<\/jats:sup>I seed implantation monotherapy technique in which a biologically effective dose (BED)\u00a0\u2267\u00a0200\u00a0Gy is applied for treatment of intermediate\u2010risk prostate cancer. This protocol is named the \u201cTen\u2010step Method,\u201d where the rationale and principle of the method are based on the following four goals: (1) The entire prostate should be covered by the prescription isodose distribution with a sufficient margin from the prostatic capsule, achieving high D90 and V100 values by <jats:sup>125<\/jats:sup>I seed implantation. (2) The high\u2010dose cloud (240\u00a0Gy) should not invade the urethra or rectum. (3) In order to achieve goals (1) and (2), make the high\u2010dose cloud intentionally along the periphery (bilateral wall to anterior wall) away from the urethra and rectum. (4) In order to achieve goal (3), seeds at the periphery, except those anterior to the rectal wall, should be placed just 1mm inside the capsule. The data obtained from a total of 137 patients with intermediate\u2010risk prostate cancer treated with low\u2010dose\u2010rate (LDR) monotherapy are shown. The dosimetry parameters were monitored at 1\u00a0month after seed implantation by using CT and MRI fusion guidance. The data at 1\u00a0month after LDR were: Average D90, BED, and V100 of <jats:sup>125<\/jats:sup>I LDR monotherapy were 194.1\u00a0Gy, 207.3\u00a0Gy, and 99%, respectively. This ten\u2010step method was reproducible in 137 patients with intermediate\u2010risk prostate cancer, allowing administration of high\u2010dose monotherapy with excellent clinical outcomes.<\/jats:p>","DOI":"10.1002\/acm2.13224","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T15:24:42Z","timestamp":1620055482000},"page":"172-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ten\u2010step method of high\u2010dose LDR <sup>125<\/sup>I brachytherapy for intermediate\u2010risk prostate cancer"],"prefix":"10.1002","volume":"22","author":[{"given":"Keisei","family":"Okamoto","sequence":"first","affiliation":[{"name":"Department of Brachytherapy for Prostate Cancer Shiga University of Medical Science Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-011-0183-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2420786"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00521-Y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.05.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2013.07.007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5114\/jcb.2020.92405"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3246613"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meddos.2003.09.005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.07.981"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.10.071"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.5114\/jcb.2017.66072"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.07.040"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.03.033"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20150981"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2013.07.004"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.08.030"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12347"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.06.067"}],"container-title":["Journal of Applied Clinical Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.13224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acm2.13224","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.13224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:39:04Z","timestamp":1744677544000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1002\/acm2.13224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,3]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/acm2.13224"],"URL":"https:\/\/doi.org\/10.1002\/acm2.13224","archive":["Portico"],"relation":{},"ISSN":["1526-9914","1526-9914"],"issn-type":[{"type":"print","value":"1526-9914"},{"type":"electronic","value":"1526-9914"}],"subject":[],"published":{"date-parts":[[2021,5,3]]},"assertion":[{"value":"2020-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}