{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:18:23Z","timestamp":1786976303665,"version":"build-2736575974"},"reference-count":62,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,4]],"date-time":"2021-04-04T00:00:00Z","timestamp":1617494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate dosimetric properties of intensity\u2010modulated proton therapy (IMPT) for simulated treatment planning in patients with atrial fibrillation (AF) targeting left atrial\u2010pulmonary vein junction (LA\u2010PVJ), in comparison with volumetric\u2010modulated arc therapy (VMAT) and helical tomotherapy (TOMO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten thoracic 4D\u2010CT scans with respiratory motion and one with cardiac motion were used for the study. Ten respiratory 4D\u2010CTs were planned with VMAT, TOMO, and IMPT for simulated AF. Targets at the LA\u2010PVJ were defined as wide\u2010area circumferential ablation line. A single fraction of 25\u00a0Gy was prescribed to all plans. The interplay effects from cardiac motion were evaluated based on the cardiac 4D\u2010CT scan. Dose\u2010volume histograms (DVHs) of the ITV and normal tissues were compared. Statistical analysis was evaluated via one\u2010way Repeated\u2010Measures ANOVA and Friedman\u2019s test with Bonferroni\u2019s multiple comparisons test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median volume of ITV was 8.72cc. All plans had adequate target coverage (V\n                      <jats:sub>23.75Gy<\/jats:sub>\n                      \u00a0\u2265\u00a099%). Compared with VMAT and TOMO, IMPT resulted in significantly lower dose of most normal tissues. For VMAT, TOMO, and IMPT plans, D\n                      <jats:sub>mean<\/jats:sub>\n                      of the whole heart was 5.52\u00a0\u00b1\u00a00.90\u00a0Gy, 5.89\u00a0\u00b1\u00a00.78\u00a0Gy, and 3.01\u00a0\u00b1\u00a00.57\u00a0Gy (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), mean dose of pericardium was 4.74\u00a0\u00b1\u00a00.76\u00a0Gy, 4.98\u00a0\u00b1\u00a00.62\u00a0Gy, and 2.59\u00a0\u00b1\u00a00.44\u00a0Gy (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and D\n                      <jats:sub>0.03cc<\/jats:sub>\n                      of left circumflex artery (LCX) was 13.96\u00a0\u00b1\u00a05.45\u00a0Gy, 14.34\u00a0\u00b1\u00a05.91\u00a0Gy, and 8.43\u00a0\u00b1\u00a07.24\u00a0Gy (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), respectively. However, no significant advantage for one technique over the others was observed when examining the D\n                      <jats:sub>0.03cc<\/jats:sub>\n                      of esophagus and main bronchi.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IMPT targeting LA\u2010PVJ for patients with AF has high potential to reduce dose to surrounding tissues compared to VMAT or TOMO. Motion mitigation techniques are critical for a particle\u2010therapy approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.13239","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:42:01Z","timestamp":1617583321000},"page":"79-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dosimetric feasibility of stereotactic ablative radiotherapy in pulmonary vein isolation for atrial fibrillation using intensity\u2010modulated proton therapy"],"prefix":"10.1002","volume":"22","author":[{"given":"Xue\u2010Ying","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng\u2010Kang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology Peking University First Hospital Beijing 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