{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:34:03Z","timestamp":1785864843699,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the accuracy of surface\u2010guided radiotherapy (SGRT) in cranial patient setup by direct comparison between optical surface imaging (OSI) and cone\u2010beam computed tomography (CBCT), before applying SGRT\u2010only setup for conventional radiotherapy of brain and nasopharynx cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>Using CBCT as reference, SGRT setup accuracy was examined based on 269 patients (415 treatments) treated with frameless cranial stereotactic radiosurgery (SRS) during 2018\u20102019. Patients were immobilized in customized head molds and open\u2010face masks and monitored using OSI during treatment. The facial skin area in planning CT was used as OSI region of interest (ROI) for automatic surface alignment and the skull was used as the landmark for automatic CBCT\/CT registration. A 6 degrees of freedom (6DOF) couch was used. Immediately after CBCT setup, an OSI verification image was captured, recording the SGRT setup differences. These differences were analyzed in 6DOFs and as a function of isocenter positions away from the anterior surface to assess OSI\u2010ROI bias. The SGRT in\u2010room setup time was estimated and compared with CBCT and orthogonal 2D kilovoltage (2DkV) setups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SGRT setup difference (magnitude) is found to be 1.0\u00a0\u00b1\u00a02.5\u00a0mm and 0.1\u02da\u00b11.4\u02da on average among 415 treatments and within 5\u00a0mm\/3\u02da with greater than 95% confidence level (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Outliers were observed for very\u2010posterior isocenters: 15 differences (3.6%) are &gt;5.0mm and 9 (2.2%) are &gt;3.0\u02da. The setup differences show minor correlations (|r| &lt; 0.45) between translational and rotational DOFs and a minor increasing trend (&lt;1.0\u00a0mm) in the anterior\u2010to\u2010posterior direction. The SGRT setup time is 0.8\u00a0\u00b1\u00a00.3\u00a0min, much shorter than CBCT (5\u00a0\u00b1\u00a02\u00a0min) and 2DkV (2\u00a0\u00b1\u00a01\u00a0min) setups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that SGRT has sufficient accuracy for fast in\u2010room patient setup and allows real\u2010time motion monitoring for beam holding during treatment, potentially useful to guide radiotherapy of brain and nasopharynx cancer with standard fractionation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.13241","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T06:45:59Z","timestamp":1617259559000},"page":"48-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Accuracy of surface\u2010guided patient setup for conventional radiotherapy of brain and nasopharynx cancer"],"prefix":"10.1002","volume":"22","author":[{"given":"Sang 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