{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:08:46Z","timestamp":1790856526299,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The integration of auto\u2010segmentation and automated treatment planning methods on a fast\u2010rotating O\u2010ring linac may improve the time efficiency of online adaptive radiotherapy workflows. This study investigates whether automated treatment planning of prostate SBRT with focal boosting on the O\u2010ring linac could generate plans that are of similar quality as those obtained through manual planning on clinical C\u2010arm linacs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For 20\u00a0men with prostate cancer, reference treatment plans were generated on a TrueBeam STx C\u2010arm linac with HD120\u00a0MLC and a TrueBeam C\u2010arm linac with Millennium 120\u00a0MLC using 6\u00a0MV flattened dual arc VMAT. Manual planning on the Halcyon fast\u2010rotating O\u2010ring linac was performed using 6\u00a0MV FFF dual arc VMAT (HA2\u2010DL10) and triple arc VMAT (HA3\u2010DL10) to investigate the performance of the dual\u2010layer MLC system. Automated planning was performed for triple arc VMAT on the Halcyon linac (ET3\u2010DL10) using the automated planning algorithms of Ethos Treatment Planning. The prescribed dose was 35\u00a0Gy to the prostate and 30\u00a0Gy to the seminal vesicles in five fractions. The iso\u2010toxic focal boost to the intraprostatic tumor nodule(s) was aimed to receive up to 50\u00a0Gy. Plan deliverability was verified using portal image dosimetry measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the C\u2010arm linacs, ET3\u2010DL10 shows increased seminal vesicles PTV coverage (D<jats:sub>99%<\/jats:sub>) and reduced high\u2010dose spillage to the bladder (V<jats:sub>37Gy<\/jats:sub>) and urethra (D<jats:sub>0.035cc<\/jats:sub>) but this came at the cost of increased high\u2010dose spillage to the rectum (V<jats:sub>38Gy<\/jats:sub>) and a higher intermediate dose spillage (D2cm). No statistically significant differences were found when benchmarking HA2\u2010DL10 and HA3\u2010DL10 with the C\u2010arm linacs. All plans passed the patient\u2010specific QA tolerance limit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Automated planning of prostate SBRT with focal boosting on the fast\u2010rotating O\u2010ring linac is feasible and achieves similar plan quality as those obtained on clinical C\u2010arm linacs using manual planning.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.13345","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T08:55:06Z","timestamp":1627462506000},"page":"59-72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Automated treatment planning of prostate stereotactic body radiotherapy with focal boosting on a fast\u2010rotating O\u2010ring linac: Plan quality comparison with C\u2010arm linacs"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7452-7073","authenticated-orcid":false,"given":"Robin","family":"De Roover","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University Hospitals Leuven Leuven Belgium"},{"name":"Department of Oncology KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Crijns","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospitals Leuven Leuven Belgium"},{"name":"Department of Oncology KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Poels","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospitals Leuven Leuven Belgium"},{"name":"Department of Oncology KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Dewit","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospitals Leuven Leuven Belgium"},{"name":"Department of Oncology KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Draulans","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospitals Leuven Leuven Belgium"},{"name":"Department of Oncology KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Haustermans","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospitals Leuven Leuven Belgium"},{"name":"Department of Oncology KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Depuydt","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospitals Leuven Leuven Belgium"},{"name":"Department of Oncology KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606220"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70040-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.09.020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.04.005"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02795-5"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2017.12.022"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.11.402"},{"key":"e_1_2_10_9_1","first-page":"1","article-title":"Focal boost to the intraprostatic tumor in external beam radiotherapy for patients with localized prostate cancer: results from the FLAME randomized phase III trial","author":"Kerkmeijer LGW","year":"2021","journal-title":"J Clin Oncol"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2020.03.015"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.8006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.03.051"},{"issue":"19","key":"e_1_2_10_13_1","first-page":"1","article-title":"Ultra\u2010hypofractionated versus conventionally fractionated radiotherapy for prostate cancer: 5\u2010year outcomes of the HYPO\u2010RT\u2010PC randomised, non\u2010inferiority, phase 3 trial","volume":"6736","author":"Widmark A","year":"2019","journal-title":"Lancet"},{"issue":"19","key":"e_1_2_10_14_1","first-page":"1","article-title":"Intensity\u2010modulated fractionated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE\u2010B): acute toxicity findings from an international, randomised, open\u2010label, phase 3, non\u2010inferiority trial","volume":"2045","author":"Brand DH","year":"2019","journal-title":"Lancet Oncol"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.3764"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2019.08.027"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2019.06.023"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.10.009"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.13380"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.056"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1120\/jacmp.v14i3.4262"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4893196"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.04.023"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2019.02.004"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.11.054"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.13396"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2019.11.015"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.12568"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.01.014"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.04.012"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.04.015"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02812-2"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.01.023"},{"key":"e_1_2_10_34_1","unstructured":"AndreoP BurnsDT HohlfeldK HuqMS KanaiT LaitanoF et al.Absorbed Dose Determination in External Beam Radiotherapy: An International Code of Practice for Dosimetry based on Standards of Absorbed Dose to Water. Technical Report Series No. 398. Iaea Trs\u2010398.2006;2006(June):183."},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.04.021"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.2307\/3583506"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(89)90972-3"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.598063"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.03.078"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2015.1037011"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.12.041"},{"issue":"1","key":"e_1_2_10_42_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y","year":"1995","journal-title":"J R Stat Soc B"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.598248"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.12810"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.13105"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00122"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.13282"},{"issue":"2019","key":"e_1_2_10_48_1","first-page":"1","article-title":"Comprehensive validation of halcyon 2.0 plans and the implementation of patient speci fic QA with multiple detector platforms","author":"Laugeman E","year":"2020","journal-title":"J Appl Clin Med Phys"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2020.09.033"}],"container-title":["Journal of Applied Clinical Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.13345","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acm2.13345","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.13345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T06:33:01Z","timestamp":1725517981000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1002\/acm2.13345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,28]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/acm2.13345"],"URL":"https:\/\/doi.org\/10.1002\/acm2.13345","archive":["Portico"],"relation":{},"ISSN":["1526-9914","1526-9914"],"issn-type":[{"value":"1526-9914","type":"print"},{"value":"1526-9914","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,28]]},"assertion":[{"value":"2021-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}