{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:19:00Z","timestamp":1786976340241,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Real\u2010time tracking systems of moving respiratory targets such as CyberKnife, Radixact, or Vero4DRT are an advanced robotic radiotherapy device used to deliver stereotactic body radiotherapy (SBRT). The internal target volume (ITV) of lung tumors is assessed through a fiducial marker fusion using four\u2010dimensional computed tomography (CT). It is important to minimize the ITV to protect normal lung tissue from exposure to radiation and the associated side effects post SBRT. However, the ITV may alter if there is a change in the position of the fiducial marker with respect to the tumor. This study investigated the relationship between fiducial marker position and the ITV in order to prevent radiation exposure of normal lung tissue, and correct target coverage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      This study retrospectively reviewed 230 lung cancer patients who received a fiducial marker for SBRT between April 2015 and September 2021. The distance of the fiducial marker to the gross tumor volume (GTV) in the expiratory (\n                      <jats:italic>d<\/jats:italic>\n                      <jats:sub>ex<\/jats:sub>\n                      ) and inspiratory (\n                      <jats:italic>d<\/jats:italic>\n                      <jats:sub>in<\/jats:sub>\n                      ) CT, and the ratio of the ITV\/V(GTV\n                      <jats:sub>ex<\/jats:sub>\n                      ), were investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Upon comparing each lobe, although there was no significant difference in the\n                      <jats:italic>d<\/jats:italic>\n                      <jats:sub>diff<\/jats:sub>\n                      and the ITV\/V(GTV\n                      <jats:sub>ex<\/jats:sub>\n                      ) between all lobes for\n                      <jats:italic>d<\/jats:italic>\n                      <jats:sub>ex<\/jats:sub>\n                      \u00a0&lt;\u00a010\u00a0mm, there was significant difference in the\n                      <jats:italic>d<\/jats:italic>\n                      <jats:sub>diff<\/jats:sub>\n                      and the ITV\/V(GTV\n                      <jats:sub>ex<\/jats:sub>\n                      ) between the lower and upper lobes for\n                      <jats:italic>d<\/jats:italic>\n                      <jats:sub>ex<\/jats:sub>\n                      \u2265 10\u00a0mm (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Moreover, there was significant difference in the\n                      <jats:italic>d<\/jats:italic>\n                      <jats:sub>diff<\/jats:sub>\n                      and the ITV\/V(GTV\n                      <jats:sub>ex<\/jats:sub>\n                      ) between\n                      <jats:italic>d<\/jats:italic>\n                      <jats:sub>ex<\/jats:sub>\n                      \u226510\u00a0mm and\n                      <jats:italic>d<\/jats:italic>\n                      <jats:sub>ex<\/jats:sub>\n                      \u00a0&lt;\u00a010\u00a0mm in all lung regions (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The ITV that had no margin from GTVs increased when\n                      <jats:italic>d<\/jats:italic>\n                      <jats:sub>ex<\/jats:sub>\n                      was \u226510\u00a0mm for all lung regions (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Furthermore, the increase in ITV tended to be greater in the lower lung lobe. These findings can help decrease the possibility of adverse events post SBRT, and correct target coverage.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.13596","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T12:10:30Z","timestamp":1649074230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fiducial marker position affects target volume in stereotactic lung irradiation"],"prefix":"10.1002","volume":"23","author":[{"given":"Hiroaki","family":"Akasaka","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology Kobe Minimally Invasive Cancer Center  Chuo\u2010ku Kobe Hyogo Japan"},{"name":"Division of Radiation Oncology Kobe University Graduate School of Medicine  Chuo\u2010ku Kobe Hyogo 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