{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:44:18Z","timestamp":1780638258305,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T00:00:00Z","timestamp":1657324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62071314"],"award-info":[{"award-number":["62071314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to dosimetrically compare volumetric\u2010modulated arc therapy (VMAT) with intensity\u2010modulated radiotherapy (IMRT) techniques using either 6\u2010 or 10\u2010MV photon beam energies in lung stereotactic body radiation therapy (SBRT) plans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty patients with primary or metastatic lung tumors eligible for SBRT were randomly selected. VMAT and IMRT treatment plans using either 6\u2010 or 10\u2010MV photon energies were generated through automatic SBRT planning software in the RayStation treatment planning system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For planning target volume, there was no difference in <jats:italic>D<\/jats:italic><jats:sub>95%<\/jats:sub> for all plans, whereas <jats:italic>D<\/jats:italic><jats:sub>2%<\/jats:sub> and <jats:italic>D<\/jats:italic><jats:sub>50%<\/jats:sub> were significantly increased by 5.22%\u20135.98% and 2.47%\u20132.59%, respectively, using VMAT<jats:sub>6\/10\u2010MV<\/jats:sub> plans compared to IMRT<jats:sub>6\/10\u2010MV<\/jats:sub> plans. When comparing the <jats:italic>D<\/jats:italic><jats:sub>max<\/jats:sub> of organs at risk (OARs), VMAT<jats:sub>6\/10\u2010MV<\/jats:sub> was 18.32%\u201347.95% lower than IMRT<jats:sub>6\/10\u2010MV<\/jats:sub> for almost all OARs. VMAT<jats:sub>6\/10\u2010MV<\/jats:sub> obviously decreased <jats:italic>D<\/jats:italic><jats:sub>mean<\/jats:sub>, <jats:italic>V<\/jats:italic><jats:sub>5Gy<\/jats:sub>, <jats:italic>V<\/jats:italic><jats:sub>10Gy<\/jats:sub>, and <jats:italic>V<\/jats:italic><jats:sub>20Gy<\/jats:sub> of whole lung by 9.68%\u201320.92% than IMRT<jats:sub>6\/10\u2010MV<\/jats:sub>. Similar results were found when comparing VMAT<jats:sub>6\u2010MV<\/jats:sub> with IMRT<jats:sub>10\u2010MV<\/jats:sub> or VMAT<jats:sub>10\u2010MV<\/jats:sub> with IMRT<jats:sub>6\u2010MV<\/jats:sub>. The differences in the <jats:italic>D<\/jats:italic><jats:sub>2%<\/jats:sub>, heterogeneity index, and conformity index between 6\u2010 and 10\u2010MV plans are not statistically significant. Plans using 6\u2010MV performed 4.68%\u20138.91% lower levels of <jats:italic>D<\/jats:italic><jats:sub>max<\/jats:sub> of spinal cord, esophagus, great vessels, and trachea and proximal bronchial tree than those using 10\u2010MV plans. Similarly, <jats:italic>D<\/jats:italic><jats:sub>mean<\/jats:sub>, <jats:italic>V<\/jats:italic><jats:sub>5Gy<\/jats:sub>, <jats:italic>V<\/jats:italic><jats:sub>10Gy<\/jats:sub>, and <jats:italic>V<\/jats:italic><jats:sub>20Gy<\/jats:sub> of whole lung were also reduced by 2.79%\u20135.25% using 6\u2010MV. For dose fall\u2010off analysis, the <jats:italic>D<\/jats:italic><jats:sub>2cm<\/jats:sub> and <jats:italic>R<\/jats:italic><jats:sub>50%<\/jats:sub> of VMAT<jats:sub>6\/10\u2010MV<\/jats:sub> were lower than those of IMRT<jats:sub>6\/10\u2010MV<\/jats:sub>. Dose fall\u2010off curve based on 10 rings was steeper for VMAT plans than IMRT plans regardless of the energy used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For lung SBRT plans, VMAT\u2010based plans significantly reduced OARs dose and steepened dose fall\u2010off curves compared to IMRT\u2010based plans. A 6\u2010MV energy level was a better choice than 10\u2010MV for lung SBRT. In addition, the dose differences between different techniques were more obvious than those between different energy levels.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.13714","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T09:14:24Z","timestamp":1657358064000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Treatment plan comparison of volumetric\u2010modulated arc therapy to intensity\u2010modulated radiotherapy in lung stereotactic body radiotherapy using either 6\u2010 or 10\u2010MV photon energies"],"prefix":"10.1002","volume":"23","author":[{"given":"Zhigong","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Biotherapy, Cancer Center West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchen","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, Cancer Center West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"He","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, Cancer Center West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, Cancer Center West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheran","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, Cancer Center West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Cancer Center West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.09.042"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3438081"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.5681"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.261"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.02.060"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.1251"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.07.1751"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2019.06.024"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2017.05.064"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.01.060"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meddos.2017.07.009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.12788"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.014"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748\u2010717X\u20106\u2010140"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.04.014"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.03.053"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.11.051"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145117"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0360\u20103016(02)02750\u20105"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2008.04.001"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.08.003"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.11.040"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2016.03.015"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014\u2010021\u201001891\u20106"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.12.022"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","unstructured":"International Commission on Radiation Units and Measurements. 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