{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:34:04Z","timestamp":1778672044702,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Success of auto\u2010segmentation is measured by the similarity between auto and manual contours that is often quantified by Dice coefficient (DC). The dosimetric impact of contour variability on inverse planning has been rarely reported. The main aim of this study is to investigate whether automatically generated organs\u2010at\u2010risk (OARs) could be used in inverse prostate stereotactic body radiation therapy (SBRT) planning and whether the dosimetric parameters are still clinically acceptable after radiation oncologists modify the OARs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>Planning computed tomography images from 10 patients treated with SBRT for prostate cancer were selected and automatically segmented by commercially available atlas\u2010based software. The automatically generated OAR contours were compared with the manually drawn contours. Two volumetric modulated arc therapy (VMAT) plans, autoRec\u2010VMAT (where only automatically generated rectums were used in optimization) and autoAll\u2010VMAT (where automatically generated OARs were used in inverse optimization) were generated. Dosimetric parameters based on the manually drawn PTV and OARs were compared with the clinically approved plans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The DCs for the rectum contours varied from 0.55 to 0.74 with a mean value of 0.665. Differences of<jats:italic>D<\/jats:italic><jats:sub>95<\/jats:sub>of the PTV between autoRec\u2010VMAT and manu\u2010VMAT plans varied from 0.03% to \u22122.85% with a mean value of \u22120.64%. Differences of<jats:italic>D<\/jats:italic><jats:sub>0.03cc<\/jats:sub>of manual rectum between the two plans varied from \u22120.86% to 9.94% with a mean value of 2.71%.<jats:italic>D<\/jats:italic><jats:sub>95<\/jats:sub>of PTV between autoAll\u2010VMAT and manu\u2010VMAT plans varied from 0.28% to \u22122.9% with a mean value \u22120.83%. Differences of<jats:italic>D<\/jats:italic><jats:sub>0.03cc<\/jats:sub>of manual rectum between the two plans varied from \u22120.76% to 6.72% with a mean value of 2.62%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study implies that it is possible to use unedited automatically generated OARs to perform initial inverse prostate SBRT planning. After radiation oncologists modify\/approve the OARs, the plan qualities based on the manually drawn OARs are still clinically acceptable, and a re\u2010optimization may not be needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.13809","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T11:58:58Z","timestamp":1666871938000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Contour similarity and its implication on inverse prostate SBRT treatment planning"],"prefix":"10.1002","volume":"24","author":[{"given":"Chenyu","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Cleveland Clinic Foundation Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingqi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cleveland Clinic Foundation Cleveland Ohio 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