{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T18:03:01Z","timestamp":1784743381553,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Geometrical uncertainties in patients can severely affect the quality of radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We evaluated the dosimetric efficacy of robust optimization for helical intensity\u2010modulated radiotherapy (IMRT) planning in the presence of patient setup uncertainty and anatomical changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two helical IMRT plans for 10 patients with localized prostate cancer were created using either minimax robust optimization (robust plan) or a conventional planning target volume (PTV) margin approach (PTV plan). Plan robustness was evaluated by creating perturbed dose plans with setup uncertainty from isocenter shifts and anatomical changes due to organ variation. The magnitudes of the geometrical uncertainties were based on the patient setup uncertainty considered during robust optimization, which was identical to the PTV margin. The homogeneity index, and target coverage (TC, defined as the V100% of the clinical target volume), and organs at risk (OAR; rectum and bladder) doses were analyzed for all nominal and perturbed plans. A statistical <jats:italic>t<\/jats:italic>\u2010test was performed to evaluate the differences between the robust and PTV plans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparison of the nominal plans showed that the robust plans had lower OAR doses and a worse homogeneity index and TC than the PTV plans. The evaluations of robustness that considered setup errors more than the PTV margin demonstrated that the worst\u2010case perturbed scenarios for robust plans had significantly higher TC while maintaining lower OAR doses. However, when anatomical changes were considered, improvement in TC from robust optimization was not observed in the worst\u2010case perturbed plans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For helical IMRT planning in localized prostate cancer, robust optimization provides benefits over PTV margin\u2013based planning, including better OAR sparing, and increased robustness against systematic patient\u2010setup errors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.13881","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T14:59:00Z","timestamp":1672239540000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effectiveness of robust optimization against geometric uncertainties in TomoHelical planning for prostate cancer"],"prefix":"10.1002","volume":"24","author":[{"given":"Takayuki","family":"Yagihashi","sequence":"first","affiliation":[{"name":"Department of Medical Physics Shonan Kamakura General Hospital  Kamakura City Kanagawa Japan"},{"name":"Graduate School of Human Health Sciences Tokyo Metropolitan University  Arakawa\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Inoue","sequence":"additional","affiliation":[{"name":"Graduate School of Human Health Sciences Tokyo Metropolitan University  Arakawa\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Shonan Kamakura General Hospital  Kamakura City Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Shonan Kamakura General Hospital  Kamakura City Kanagawa Japan"},{"name":"Medical Physics Laboratory, Division of Health Science, Graduate School of Medicine Osaka University  Suita\u2010shi Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yamano","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Shonan Kamakura General Hospital  Kamakura City Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Shonan Kamakura General Hospital  Kamakura City Kanagawa Japan"},{"name":"Graduate School of Engineering Kyoto University  Nishikyo\u2010ku Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Yamakabe","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Shonan Kamakura General Hospital  Kamakura City Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Shonan Kamakura General Hospital  Kamakura City Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoko","family":"Omura","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Shonan Kamakura General Hospital  Kamakura City Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Shonan Kamakura General Hospital  Kamakura City Kanagawa Japan"},{"name":"Department of Radiation Oncology Juntendo University  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1606220"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rry089"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360\u20103016(00)00518\u20106"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3556559"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4737113"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.06.2454"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.03.017"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.12291"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152477"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2021.03.008"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2019.03.019"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4916092"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.21873\/INVIVO.12548"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/51\/13\/R24"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.596958"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.7785\/tcrt.2012.500193"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014\u2010016\u20100707\u20106"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014\u2010019\u20101353\u20106"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.03.046"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jrras.2022.01.007"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.7785\/tcrt.2012.500348"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604\u2010017\u20100696\u2010x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014\u2010014\u20100247\u2010x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2021.08.005"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14923"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13014\u2010016\u20100634\u20106"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014\u2010020\u20101483\u2010x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754\u20109485.12703"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14169"},{"key":"e_1_2_10_32_1","unstructured":"RaySearch Laboratories AB.Multi\u2010criteria optimization for tomotherapy. White Paper. 2018."},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/abd591"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jicru\/ndq001"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2019.12.006"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.01.003"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.05.007"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2019.08.027"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2017.09.032"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.12.008"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/aa9c1c"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14132"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2022.02.0"}],"container-title":["Journal of Applied Clinical Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.13881","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acm2.13881","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.13881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T18:11:56Z","timestamp":1692727916000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1002\/acm2.13881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,28]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/acm2.13881"],"URL":"https:\/\/doi.org\/10.1002\/acm2.13881","archive":["Portico"],"relation":{},"ISSN":["1526-9914","1526-9914"],"issn-type":[{"value":"1526-9914","type":"print"},{"value":"1526-9914","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,28]]},"assertion":[{"value":"2022-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13881"}}