{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:42:17Z","timestamp":1790772137142,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cardiac radioablation (CR) is a noninvasive treatment option for patients with refractory ventricular tachycardia (VT) during which high doses of radiation, typically 25\u00a0Gy, are delivered to myocardial scar. In this study, we investigate motion from cardiac cycle and evaluate the dosimetric impact in a cohort of patients treated with CR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included eight patients treated at our institution who had respiratory\u2010correlated and ECG\u2010gated 4DCT scans acquired within 2 weeks of CR. Deformable image registration was applied between maximum systole (SYS) and diastole (DIAS) CTs to assess cardiac motion. The average respiratory\u2010correlated CT (AVG<jats:sub>resp<\/jats:sub>) was deformably registered to the average cardiac (AVG<jats:sub>cardiac<\/jats:sub>), SYS, and DIAS CTs, and contours were propagated using the deformation vector fields (DVFs). Finally, the original treatment plan was recalculated on the deformed AVG<jats:sub>resp<\/jats:sub> CT for dosimetric assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Motion magnitudes were measured as the mean (SD) value over the DVFs within each structure. Displacement during the cardiac cycle for all chambers was 1.4 (0.9) mm medially\/laterally (ML), 1.6 (1.0) mm anteriorly\/posteriorly (AP), and 3.0 (2.8) mm superiorly\/inferiorly (SI). Displacement for the 12 distinct clinical target volumes (CTVs) was 1.7 (1.5) mm ML, 2.4 (1.1) mm AP, and 2.1 (1.5) SI. Displacements between the AVG<jats:sub>resp<\/jats:sub> and AVG<jats:sub>cardiac<\/jats:sub> scans were 4.2 (2.0) mm SI and 5.8 (1.4) mm total. Dose recalculations showed that cardiac motion may impact dosimetry, with dose to 95% of the CTV dropping from 27.0 (1.3) Gy on the AVG<jats:sub>resp<\/jats:sub> to 20.5 (7.1) Gy as estimated on the AVG<jats:sub>cardiac<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cardiac CTV motion in this patient cohort is on average below 3\u00a0mm, location\u2010dependent, and when not accounted for in treatment planning may impact target coverage. Further study is needed to assess the impact of cardiac motion on clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.13925","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T05:57:27Z","timestamp":1675749447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cardiac motion and its dosimetric impact during radioablation for refractory ventricular tachycardia"],"prefix":"10.1002","volume":"24","author":[{"given":"Joseph","family":"Harms","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Schreibmann","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Winship Cancer Institute of Emory University  Atlanta Georgia 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