{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:28:14Z","timestamp":1759742894993,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aimed to assess the accuracy and dosimetric impact of the Acuros XB (AXB) algorithm compared to the Anisotropic Analytical Algorithm (AAA) in two situations. First, simple phantom geometries were set and analyzed; moreover, volumetric modulated arc therapy (VMAT) clinical plans for Head &amp; Neck and lung cases were calculated and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>First, a phantom study was performed to compare the algorithms with radiochromic EBT3 film doses using one PMMA slab phantom and two others containing foam or air gap. Subsequently, a clinical study was conducted, including 20 Head &amp; Neck and 15 lung cases irradiated with the VMAT technique. The treatment plans calculated by AXB and AAA were evaluated in terms of planning target volume (PTV) coverage (V<jats:sub>95%<\/jats:sub>), dose received by relevant organs at risk (OARs), and the impact of using AXB with a grid size of 1\u00a0mm. Finally, patient\u2010specific quality assurance (PSQA) was performed and compared for 17 treatment plans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Phantom dose calculations showed a better agreement of AXB with the film measurements. In the clinical study, AXB plans exhibited lower Conformity Index and PTV V<jats:sub>95%<\/jats:sub>, higher maximum PTV dose, and lower mean and minimum PTV doses for all anatomical sites. The most notable differences were detected in regions of intense heterogeneity. AXB predicted lower doses for the OARs, while the calculation time with a grid size of 1\u00a0mm was remarkably higher. Regarding PSQA, although AAA was found to exhibit slightly higher gamma passing rates, the difference did not affect the AXB treatment plan quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AXB demonstrated higher accuracy than AAA in dose calculations of both phantom and clinical conditions, specifically in interface regions, making it suitable for sites with large heterogeneities. Hence, such dosimetric differences between the two algorithms should always be considered in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.14051","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T09:34:32Z","timestamp":1687599272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dosimetric comparison and evaluation of two computational algorithms in VMAT treatment plans"],"prefix":"10.1002","volume":"24","author":[{"given":"Maria","family":"Tsimpoukelli","sequence":"first","affiliation":[{"name":"2nd Department of Radiology, Medical Physics Unit, School of Medicine, Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Patatoukas","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, Medical Physics Unit, School of Medicine, Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Chalkia","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, Medical Physics Unit, School of Medicine, Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Kollaros","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, Medical Physics Unit, School of Medicine, Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andromachi","family":"Kougioumtzopoulou","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, Radiation Oncology Unit, School of Medicine, Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitra","family":"Michaletou","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, Radiation Oncology Unit, School of Medicine, Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassilis","family":"Kouloulias","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, Radiation Oncology Unit, School of Medicine, Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2977-7895","authenticated-orcid":false,"given":"Kalliopi","family":"Platoni","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, Medical Physics Unit, School of Medicine, Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"International Commission on Radiation Units and Measurements (ICRU). 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