{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:10:54Z","timestamp":1773493854443,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017531","name":"Medical and Health Research Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2021PY002"],"award-info":[{"award-number":["2021PY002"]}],"id":[{"id":"10.13039\/501100017531","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Personalized precision irradiation of patients with left\u2010sided breast cancer is possible by examining the setup errors of 3\u2010 and 4\u2010mm gated window widths for those treated with deep inspiration breath\u2010hold (DIBH) treatment. An observational study was performed via a retrospective analysis of 250 cone\u2010beam computed tomography (CBCT) images of 60 left\u2010breast cancer patients who underwent whole\u2010breast radiotherapy with the DIBH technique between January 2021 and 2022 at our hospital. Among them, 30 patients had a gated window width of 3\u00a0mm, while the remaining 30 had a gated window width of 4\u00a0mm; both groups received radiotherapy using DIBH technology. All patients underwent CBCT scans once a week, and the setup errors in the left\u2010right (x\u2010axis), inferior\u2010superior (y\u2010axis), and anterior\u2010posterior (z\u2010axis) directions were recorded. The clinical\u2010to\u2010planning target volume (CTV\u2010PTV) margins of the two gating windows were calculated using established methods. The setup error in the Y direction was 1.69\u00a0\u00b1\u00a01.33\u00a0mm for the 3\u2010mm \u2013 wide gated window and 2.42\u00a0\u00b1\u00a03.02\u00a0mm for the 4\u2010mm \u2013 wide gated window. The two groups had statistically significant differences in the overall mean setup error (Dif 0.7, 95% CI 0.15\u20131.31, <jats:italic>t<\/jats:italic>\u00a0=\u00a02.48, <jats:italic>p<\/jats:italic>=\u00a00.014). The Z\u2010direction setup error was 2.32\u00a0\u00b1\u00a02.12\u00a0mm for the 3\u2010mm \u2013 wide gated window and 3.15\u00a0\u00b1\u00a03.34\u00a0mm for the 4\u2010mm \u2013 wide gated window. The overall mean setup error was statistically significant between the two groups (Dif 0.8, 95% CI 0.13\u20131.53, <jats:italic>t<\/jats:italic>=\u00a02.34, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.020). There was no significant difference in the X\u2010direction setup error (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). Therefore, the CTV\u2010PTV margin values for a 3\u2010mm gated window width in the X, Y, and Z directions are 5.51, 5.15, and 7.28\u00a0mm, respectively; those for a 4\u2010mm gated window width in the X, Y, and Z directions are 5.52, 8.16, and 10.21\u00a0mm, respectively. The setup errors of the 3\u2010mm \u2013 wide gating window are smaller than those of the 4\u2010mm \u2013 wide gating window in the three dimensions. Therefore, when the patient's respiratory gating window width is reduced, the margin values of CTV\u2010PTV can be reduced to increase the distance between the PTV and the organs at risk (OARs), which ensures adequate space for the dose to decrease, resulting in lower dose exposure to the OARs (heart, lungs, etc.), thus sparing the OARs from further damage. However, some patients with poor pulmonary function or unstable breathing amplitudes must be treated with a slightly larger gating window. Therefore, this study lays a theoretical basis for personalized precision radiotherapy, which can save time and reduce manpower in the delivery of clinical treatment to a certain extent. Another potential benefit of this work is to bring awareness to the potential implications of a slightly larger gating window during treatment without considering the resulting dosimetric impact.<\/jats:p>","DOI":"10.1002\/acm2.14116","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T07:20:31Z","timestamp":1691133631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Correlation between the setting of gating window width and setup accuracy in left breast cancer radiotherapy based on deep inspiration breath hold"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8276-7461","authenticated-orcid":false,"given":"Li","family":"Yucheng","sequence":"first","affiliation":[{"name":"Cancer Center Department of Radiation Oncology Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College Hangzhou Zhejiang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao","family":"Yibo","sequence":"additional","affiliation":[{"name":"Department of Cancer Radiotherapy and Chemotherapy Quzhou Hospital of Zhejiang Medical and Health Group (Zhejiang Quhua Hospital) Quzhou Zhejiang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan","family":"Wenming","sequence":"additional","affiliation":[{"name":"Cancer Center Department of Radiation Oncology Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College Hangzhou Zhejiang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Yongshi","sequence":"additional","affiliation":[{"name":"Cancer Center Department of Radiation Oncology Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College Hangzhou Zhejiang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Qiang","sequence":"additional","affiliation":[{"name":"Cancer Center Department of Radiation Oncology Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College Hangzhou Zhejiang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu","family":"Lingyun","sequence":"additional","affiliation":[{"name":"Cancer Center Department of Radiation Oncology Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College Hangzhou Zhejiang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Center Department of Radiation Oncology Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College Hangzhou Zhejiang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YingHao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Center Department of Radiation Oncology Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College Hangzhou Zhejiang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ding","family":"jieni","sequence":"additional","affiliation":[{"name":"Cancer Center Department of Radiation Oncology Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College Hangzhou Zhejiang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8722-0999","authenticated-orcid":false,"given":"Chen","family":"Weijun","sequence":"additional","affiliation":[{"name":"Cancer Center Department of Radiation Oncology Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College Hangzhou Zhejiang P. R. 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