{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:25:10Z","timestamp":1788207910060,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To demonstrate a new individualized 3D printed oral stent in radiotherapy of nasopharyngeal carcinoma (NPC) patients and carry out a comparative analysis combining with clinical case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Thirty NPC patients treated in our institution from September 2021 to October 2022 were prospectively enrolled. An individualized 3D printed oral stent was designed for each patient, and one set of computed tomography (CT) slices were obtained with \/without wearing the oral stent, respectively. After delineation of target volumes and organs at risk (OARs) on the two CT slices, we finished two treatment plans by using the same target objectives, critical constraints and plan setup for each patient. Finally, the dose distribution and other dosimetric parameters of target volumes and OARs between the two plans were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Tongue volume and tongue length outside of mouth was 10.4\u00a0\u00b1\u00a02.5\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      and 2.8\u00a0\u00b1\u00a00.6\u00a0cm, respectively, distance between dorsal surface of oral tongue and plate increased from 0.3\u00a0\u00b1\u00a00.3\u00a0cm to 2.2\u00a0\u00b1\u00a00.5\u00a0cm by wearing the oral stent. For the target volume, there was no significant difference. However,\n                      <jats:italic>D<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      of tongue, tongue tip and periglottis decreased significantly from 6352.6\u00a0\u00b1\u00a0259.9\u00a0cGy to 5994.9\u00a0\u00b1\u00a0478.9\u00a0cGy, 3499.8\u00a0\u00b1\u00a0250.6\u00a0cGy to 3357.7\u00a0\u00b1\u00a0158.0\u00a0cGy and 6345.5\u00a0\u00b1\u00a0171.0\u00a0cGy to 6133.4\u00a0\u00b1\u00a0263.3\u00a0cGy, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.000);\n                      <jats:italic>D<\/jats:italic>\n                      <jats:sub>mean<\/jats:sub>\n                      of tongue, tongue tip and periglottis decreased significantly from 3714.7\u00a0\u00b1\u00a0204.2\u00a0cGy to 3169.7\u00a0\u00b1\u00a0200.9\u00a0cGy, 3060.8\u00a0\u00b1\u00a0216.2\u00a0cGy to 2509.6\u00a0\u00b1\u00a0196.7\u00a0cGy and 3853.3\u00a0\u00b1\u00a0224.9\u00a0cGy to 3079.3\u00a0\u00b1\u00a0222.0\u00a0cGy, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.000).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The individualized 3D printed oral stent can reduce the dose of oral tissues and organs, so as to reduce the oral adverse reactions and improve the compliance of patients and the quality of their life. The technique can be used in radiotherapy of NPC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.14145","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T13:28:18Z","timestamp":1694093298000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Wearing individualized 3D printed oral stent to protect normal tissues in patients with nasopharyngeal carcinoma during radiotherapy"],"prefix":"10.1002","volume":"24","author":[{"given":"Wanfu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology General Hospital of Ningxia Medical University  Yinchuan Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology General Hospital of Ningxia Medical University  Yinchuan Ningxia 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