{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:43:45Z","timestamp":1789875825457,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:00:00Z","timestamp":1694822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>MRI is preferred for brain tumor assessment, while CT is used for radiotherapy simulation. This study evaluated immobilization equipment's impact on CT\u2010MRI registration accuracy and MR image quality in RT setup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included CT and MR images from 11 patients with high\u2010grade glioma, all of whom were immobilized with a thermoplastic mask and headrest. T1\u2010 and T2\u2010weighted MR images were acquired using an MR head coil in a diagnostic setup (DS) and a body matrix coil in RT setup. To assess MR image quality, signal\u2010to\u2010noise ratio (SNR) and contrast\u2010to\u2010noise ratio (CNR) were considered in some dedicated regions of interest. We also evaluated the impact of immobilization equipment on CT\u2010MRI rigid registration using line profile and external contour methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The CNR and SNR reduction was in the RT setup of imaging. This was more evident in T1\u2010weighted images than in T2\u2010weighted ones. The SNR decreased by 14.91% and 12.09%, while CNR decreased by 25.12% and 20.15% in T1\u2010 and T2\u2010weighted images, respectively. The immobilization equipment in the RT setup decreased the mean error in rigid registration by 1.02\u00a0mm. The external contour method yielded Dice similarity coefficients (DSC) of 0.84 and 0.92 for CT\u2010DS MRI and CT\u2010RT MRI registration, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The image quality reduction in the RT setup was due to the imaged region's anatomy and its position relative to the applied coil. Furthermore, optimizing the pulse sequence is crucial for MR imaging in RT applications. Although the use of immobilization equipment may decrease the image quality in the RT setup, it does not affect organ delineation, and the image quality is still satisfactory for this purpose. Also, the use of immobilization equipment in the RT setup has increased registration accuracy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.14162","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T22:54:26Z","timestamp":1694904866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The influence of patient positioning and immobilization equipment on MR image quality and image registration in radiation therapy"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4736-4181","authenticated-orcid":false,"given":"Atefeh","family":"Rostami","sequence":"first","affiliation":[{"name":"Department of Medical Physics and Radiological Sciences Sabzevar University of Medical Sciences  Sabzevar 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