{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:05:24Z","timestamp":1784027124873,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We examined the effects of reducing the planning target volume (PTV) margin in MR\u2010guided radiotherapy (MRgRT) on the distribution of radiation dose to target volumes and organs\u2010at\u2010risk (OARs). Thus, we compared MR\u2010Linac (MRL) plans with and without reduced margin and intensity\u2010modulated radiotherapy (IMRT) plan with conventional linac for low\u2010risk prostate cancer patients receiving 36.25\u00a0Gy in five fractions of ultra\u2010hypofractionated radiation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty low\u2010risk prostate cancer patients treated with 1.5\u00a0T MR\u2010Linac were evaluated.\u00a0The same planning CT images were used for four plans: the MRL\u2010R plan with reduced margin planning target volume (PTV\u2010R) and the MRL\u2010N plan with normal margin PTV (PTV\u2010N), which is also used for IMRT plan. In four plans, PTV doses, organs\u2010at\u2010risk (OARs) doses, the homogeneity index (HI), and monitor units were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All plans met the criteria for PTV coverage and OARs dose constraints. The maximum and mean PTV doses were significantly higher in the MRL\u2010R and MRL\u2010N plans compared to the IMRT plan. The HI was lowest in the IMRT plan (0.040\u00a0\u00b1\u00a00.013) and highest in the MRL\u2010N plan (0.055\u00a0\u00b1\u00a00.012; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). There was no significant difference in the PTV dosimetric parameters between the MRL\u2010R and the MRL\u2010N plans. The high doses in the rectum was significantly lower in the MRL\u2010R compared to other plans. The bladder V36.25\u00a0Gy was significantly lower in the MRL\u2010R plan (2.43\u00a0\u00b1\u00a01.87\u00a0Gy) compared to MRL\u2010N (4.50\u00a0\u00b1\u00a02.42\u00a0Gy; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), and IMRT plans (4.76\u00a0\u00b1\u00a02.77\u00a0Gy; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). There was no significant difference in the low\u2010dose volumes of the body, maximum femur doses, or monitor units across each plan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ultra\u2010hypofractionated MR\u2010guided RT with 1.5\u00a0T MRL is dosimetrically feasible for patients with prostate cancer. The improved soft tissue contrast and the online adaptive plan for 1.5\u00a0T MR\u2010Linac allows for PTV margin reduction resulted in a significant dose reduction in OARs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.14179","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T07:30:20Z","timestamp":1701156620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The impact of margin reduction on radiation dose distribution of ultra\u2010hypofractionated prostate radiotherapy utilizing a 1.5\u2010T MR\u2010Linac"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2742-9021","authenticated-orcid":false,"given":"Cem","family":"Onal","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Radiation Oncology Baskent University  Ankara Turkey"},{"name":"Adana Dr. Turgut Noyan Research and Treatment Center Department of Radiation 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Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gungor","family":"Arslan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Radiation Oncology Baskent University  Ankara 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