{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T07:31:07Z","timestamp":1753860667714,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T00:00:00Z","timestamp":1703462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Organ\u2010at\u2010risk (OAR) sparing is often assessed using an overlap volume\u2010based parameter, defined as the ratio of the volume of OAR that overlaps the planning target volume (PTV) to the whole OAR volume. However, this conventional overlap\u2010based predictive parameter (COPP) does not consider the volume relationship between the PTV and OAR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We propose a new overlap\u2010based predictive parameter that consider the PTV volume. The effectiveness of proposed overlap\u2010based predictive parameter (POPP) is evaluated compared with COPP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We defined as POPP\u00a0=\u00a0(overlap volume between OAR and PTV\/OAR volume) \u00d7 (PTV volume\/OAR volume). We generated intensity modulated radiation therapy (IMRT) based on step and shoot technique, and volumetric modulated arc therapy (VMAT) plans with the Auto\u2010Planning module of Pinnacle<jats:sup>3<\/jats:sup> treatment planning system (v14.0, Philips Medical Systems, Fitchburg, WI) using the American Association of Physicists in Medicine Task Group (TG119) prostate phantom. The relationship between the position and size of the prostate phantom was systematically modified to simulate various geometric arrangements. The correlation between overlap\u2010based predictive parameters (COPP and POPP) and dose\u2010volume metrics (mean dose, V<jats:sub>70Gy<\/jats:sub>, V<jats:sub>60Gy<\/jats:sub>, and V<jats:sub>37.5\u00a0Gy<\/jats:sub> for rectum and bladder) was investigated using linear regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results indicated POPP was better than COPP in predicting intermediate\u2010dose metrics. The bladder results showed a trend similar to that of the rectum. The correlation coefficient of POPP was significantly greater than that of COPP in\u00a0&lt;\u00a062\u00a0Gy (82% of the prescribed dose) region for IMRT and in\u00a0&lt;\u00a055\u00a0Gy (73% of the prescribed dose) region for VMAT regarding the rectum (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>POPP is superior to COPP for creating predictive models at an intermediate\u2010dose level. Because rectal bleeding and bladder toxicity can be associated with intermediate\u2010doses as well as high\u2010doses, it is important to predict dose\u2010volume metrics for various dose levels. POPP is a useful parameter for predicting dose\u2010volume metrics and assisting the generation of treatment plans.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.14250","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T06:03:45Z","timestamp":1703570625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A new predictive parameter for dose\u2010volume metrics in intensity\u2010modulated radiation therapy planning for prostate cancer: Initial phantom study"],"prefix":"10.1002","volume":"25","author":[{"given":"Yuki","family":"Saito","sequence":"first","affiliation":[{"name":"Graduate School of Biomedical Science and Engineering Hokkaido University  Sapporo 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