{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:32:47Z","timestamp":1753885967980,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the potential of quantitative parameters of the hydrogel spacer distribution as predictors for separating the rectum from the planning target volume (PTV) in linear\u2010accelerator\u2010based stereotactic body radiotherapy (SBRT) for prostate cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010five patients underwent insertion of a hydrogel spacer and were divided into groups 1 and 2 of the PTV separated from and overlapping with the rectum, respectively. Prescribed doses of 36.25\u201345\u00a0Gy in five fractions were delivered to the PTV. The spacer cover ratio (SCR) and hydrogel\u2013implant quality score (HIQS) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dosimetric and quantitative parameters of the hydrogel spacer distribution were compared between the two groups. For PTV, <jats:italic>D<\/jats:italic><jats:sub>99%<\/jats:sub> in group 1 (<jats:italic>n<\/jats:italic>\u00a0=\u00a029) was significantly higher than that in group 2 (<jats:italic>n<\/jats:italic>\u00a0=\u00a026), and <jats:italic>D<\/jats:italic><jats:sub>max<\/jats:sub>, <jats:italic>D<\/jats:italic><jats:sub>0.03cc<\/jats:sub>, <jats:italic>D<\/jats:italic><jats:sub>1cc<\/jats:sub>, and <jats:italic>D<\/jats:italic><jats:sub>10%<\/jats:sub> for the rectum were significantly lower in group 1 than in group 2. The SCR for prostate (89.5\u00a0\u00b1\u00a012.2%) in group 1 was significantly higher (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) than that in group 2 (74.7\u00a0\u00b1\u00a010.3%). In contrast, the HIQS values did not show a significant difference between the groups. An area under the curve of 0.822 (95% confidence interval, 0.708\u20130.936) for the SCR was obtained with a cutoff of 93.6%, sensitivity of 62.1%, and specificity of 100%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The SCR seems promising to predict the separation of the rectum from the PTV in linear\u2010accelerator\u2010based SBRT for prostate cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.14294","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T08:41:17Z","timestamp":1707295277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Relationship between hydrogel spacer distribution and dosimetric parameters in linear\u2010accelerator\u2010based stereotactic body radiotherapy for prostate cancer"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6170-1471","authenticated-orcid":false,"given":"Shingo","family":"Ohira","sequence":"first","affiliation":[{"name":"Department of Comprehensive Radiation Oncology The University of Tokyo  Tokyo Japan"},{"name":"Department of Medical Physics and Engineering Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideomi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Radiology The University of Tokyo Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanari","family":"Minamitani","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Radiation Oncology The University of Tokyo  Tokyo 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