{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:31:01Z","timestamp":1791725461396,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Experimental patient\u2010specific QA (PSQA) is a time and resource\u2010intensive process, with a poor sensitivity in detecting errors. Radiation therapy facilities aim to substitute it by means of independent dose calculation (IDC) in combination with a comprehensive beam delivery QA program. This paper reports on the commissioning of the IDC software tool myQA\u00a0iON (IBA Dosimetry) for proton therapy and its clinical implementation at the MedAustron Ion Therapy Center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The IDC commissioning work included the validation of the beam model, the implementation and validation of clinical CT protocols, and the evaluation of patient treatment data. Dose difference maps, gamma index distributions, and pass rates (GPR) have been reviewed. The performance of the IDC tool has been assessed and clinical workflows, simulation settings, and GPR tolerances have been defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Beam model validation showed agreement of ranges within\u00a0\u00b1\u00a00.2\u00a0mm, Bragg\u2010Peak widths within\u00a0\u00b1\u00a00.1\u00a0mm, and spot sizes at various air gaps within\u00a0\u00b1\u00a05% compared to physical measurements. Simulated dose in 2D reference fields deviated by\u00a0\u20100.3%\u00a0\u00b1\u00a00.5%, while 3D dose distributions differed by 1.8% on average to measurements. Validation of the CT calibration resulted in systematic differences of 2.0% between IDC and experimental data for tissue like samples. GPRs of 99.4\u00a0\u00b1\u00a00.6% were found for head, head and neck, and pediatric CT protocols on a 2%\/2\u00a0mm gamma criterion. GPRs for the adult abdomen protocol were at 98.9% on average with 3%\/3\u00a0mm. Root causes of GPR outliers, for example, implants were identified and evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IDC has been successfully commissioned and integrated into the MedAustron clinical workflow for protons in 2021. IDC has been stepwise and safely substituting experimental PSQA since February 2021. The initial reduction of proton experimental PSQA was about 25% and reached up to 90% after 1 year.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.14328","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T04:39:52Z","timestamp":1711773592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Commissioning and clinical implementation of an independent dose calculation system for scanned proton beams"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5475-8170","authenticated-orcid":false,"given":"Ralf","family":"Dreindl","sequence":"first","affiliation":[{"name":"MedAustron Ion Therapy Center  Wiener Neustadt Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Bolsa\u2010Ferruz","sequence":"additional","affiliation":[{"name":"MedAustron Ion Therapy Center  Wiener Neustadt 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