{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:52:54Z","timestamp":1784685174699,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Regional lymph node (LN) volume decreases after neoadjuvant therapy, requiring a tracer for more accurate detection. Nano\u2010carbon tracer is a third\u2010generation tracer with several advantages, but its use for LN detection after neoadjuvant chemoradiotherapy for middle and low rectal cancer remains unclear. Therefore, this study investigated the effects and safety of anoscope\u2010guided subrectal injections of nano\u2010carbon suspension in this patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study retrospectively reviewed the medical records of 45 patients with middle and low rectal cancer admitted to our institution from March 2019 to March 2022. All patients received preoperative neoadjuvant chemotherapy and radiotherapy and were divided into nano\u2010carbon injection (<jats:italic>n<\/jats:italic>\u00a0=\u00a023; anoscope\u2010guided injections of nano\u2010carbon suspension in the rectal submucosa 2\u00a0cm above the dentate line 24\u00a0h preoperatively) and control (<jats:italic>n<\/jats:italic>\u00a0=\u00a022; directly underwent surgery) groups. The LN detection and complication rates were compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total and mean numbers of LNs and small LNs and the number of patients with\u00a0&gt;\u00a012 LNs were significantly higher in the nano\u2010carbon injection group than in the control group. The total number of positive LNs and LN metastasis did not differ between the groups, nor did the anastomotic leakage, bleeding, stenosis, and abscess occurrence rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anoscope\u2010guided nano\u2010carbon lymphatic tracing increased the LN detection rate, caused less trauma, and resulted in fewer postoperative complications than the direct surgical procedure. Thus, it is an effective, safe, and practical method that may improve dissections and the postoperative pathological staging accuracy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.14406","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T20:08:41Z","timestamp":1717186121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical value of nano\u2010carbon lymphatic tracer for regional lymph node dissections of rectal cancer after neoadjuvant chemoradiotherapy"],"prefix":"10.1002","volume":"25","author":[{"given":"Feng","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Anorectal surgery Dongyang People Hospital (affiliated Dongyang Hospital of Wenzhou Medical University)  Dongyang, Zhejiang province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anorectal surgery Dongyang People Hospital (affiliated Dongyang Hospital of Wenzhou Medical University)  Dongyang, Zhejiang province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anorectal surgery Dongyang People Hospital (affiliated Dongyang Hospital of Wenzhou Medical University)  Dongyang, Zhejiang province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lelin","family":"Pan","sequence":"additional","affiliation":[{"name":"The First Affilated Hospital Zhejiang University School of Medicine Qingchunlu  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anorectal surgery Dongyang People Hospital (affiliated Dongyang Hospital of Wenzhou Medical University)  Dongyang, Zhejiang province 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