{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:25:47Z","timestamp":1762957547821,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["212148"],"award-info":[{"award-number":["212148"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In modern positron emission tomography (PET) with multi\u2010modality imaging (e.g., PET\/CT and PET\/MR), the attenuation correction (AC) is the single largest correction factor for image reconstruction. One way to assess AC methods and other reconstruction parameters is to utilize software\u2010based simulation tools, such as a lesion insertion tool. Extensive validation of these simulation tools is required to ensure results of the study are clinically meaningful.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate different PET AC methods using a synthetic lesion insertion tool that simulates lesions in a patient cohort that has both PET\/MR and PET\/CT images. To further demonstrate how lesion insertion tool may be used to extend knowledge of PET reconstruction parameters, including but not limited to AC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lesion quantitation is compared using conventional Dixon\u2010based MR\u2010based AC (MRAC) to that of using CT\u2010based AC (CTAC, a \u201cground truth\u201d). First, the pre\u2010existing lesions were simulated in a similar environment; a total of 71 lesions were identified in 18 pelvic PET\/MR patient images acquired with a time\u2010of\u2010flight simultaneous PET\/MR scanner, and matched lesions were inserted contralaterally on the same axial slice. Second, synthetic lesions were inserted into four anatomic target locations in a cohort of four patients who didn't have any observed clinical lesions in the pelvis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The matched lesion insertions resulted in unity between the lesion error ratios (mean SUVs), demonstrating that the inserted lesions successfully simulated the original lesions. In the second study, the inserted lesions had distinct characteristics by target locations and demonstrated negative max\u2010SUV%diff trends for bone\u2010dominant sites across the patient cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current work demonstrates that the applied lesion insertion tool can simulate uptake in pelvic lesions and their expected SUV values, and that the lesion insertion tool can be extended to evaluate further PET reconstruction corrections and algorithms and their impact on quantitation accuracy and precision.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.14507","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T17:42:03Z","timestamp":1725471723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of lesion insertion tool in pelvis PET\/MR data with applications to attenuation correction method development"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8754-3250","authenticated-orcid":false,"given":"Yutaka","family":"Natsuaki","sequence":"first","affiliation":[{"name":"Keck School of Medicine of USC, University of Southern California Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Leynes","sequence":"additional","affiliation":[{"name":"iSono Health Inc. South San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Wangerin","sequence":"additional","affiliation":[{"name":"GE Healthcare  Waukesha Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdjoub","family":"Hamdi","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine in St. Louis St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhejit","family":"Rajagopal","sequence":"additional","affiliation":[{"name":"University of California, San Francisco San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul E.","family":"Kinahan","sequence":"additional","affiliation":[{"name":"University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Laforest","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine in St. Louis St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peder E. Z.","family":"Larson","sequence":"additional","affiliation":[{"name":"University of California, San Francisco San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Hope","sequence":"additional","affiliation":[{"name":"University of California, San Francisco San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara St.","family":"James","sequence":"additional","affiliation":[{"name":"University of Utah Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.598392"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5152\/dir.2014.14008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JMI.4.1.011013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sult.2010.10.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2017.01.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470\u20107330.2013.0005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2017.01.001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00018"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2016.12.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/snuc.2003.127307"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22459"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21492"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.054726"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.12122"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.198051"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14045"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40658\u2010020\u201000320\u2010z"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JMI.7.2.022412"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JMI.8.5.056001"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40658\u2010021\u201000416\u20100"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40658\u2010023\u201000590\u20103"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JMI.4.1.011002"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2010.2040188"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2967\/numed.114.148817"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/56\/1\/010"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.159301"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2018.2832613"}],"container-title":["Journal of Applied Clinical Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.14507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T18:05:40Z","timestamp":1730916340000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1002\/acm2.14507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/acm2.14507"],"URL":"https:\/\/doi.org\/10.1002\/acm2.14507","archive":["Portico"],"relation":{},"ISSN":["1526-9914","1526-9914"],"issn-type":[{"type":"print","value":"1526-9914"},{"type":"electronic","value":"1526-9914"}],"subject":[],"published":{"date-parts":[[2024,9,4]]},"assertion":[{"value":"2024-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14507"}}