{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:17:13Z","timestamp":1791926233492,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T00:00:00Z","timestamp":1728172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102135"],"award-info":[{"award-number":["82102135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["DUT23YG130"],"award-info":[{"award-number":["DUT23YG130"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2022\u2010YGJC\u201036"],"award-info":[{"award-number":["2022\u2010YGJC\u201036"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>In the current clinical diagnostic process, the gold standard for lymph node metastasis (LNM) diagnosis is histopathological examination following surgical lymphadenectomy. Developing a non\u2010invasive and preoperative method for predicting LNM is necessary and holds significant clinical importance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We develop a ranking attention multiple instance learning (RA\u2010MIL) model that integrates convolutional neural networks (CNNs) and ranking attention pooling to diagnose LNM from T2 MRI. Our RA\u2010MIL model applies the CNNs to derive imaging features from 2D MRI slices and employs ranking attention pooling to create patient\u2010level feature representation for diagnostic classification. Based on the MIL and attention theory, informative regions of top\u2010ranking MRI slices from LNM\u2010positive patients are visualized to enhance the interpretability of automatic LNM prediction. This retrospective study collected 300 female patients with cervical cancer who underwent T2\u2010weighted magnetic resonance imaging (MRI) scanning and histopathological diagnosis from one hospital (289 patients) and one open\u2010source dataset (11 patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our RA\u2010MIL model delivers promising LNM prediction performance, achieving the area under the receiver operating characteristic curve (AUC) of 0.809 on the internal test set and 0.833 on the public dataset. Experiments show significant improvements in LNM status prediction using the proposed RA\u2010MIL model compared with other state\u2010of\u2010the\u2010art (SOTA) comparative deep learning models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The developed RA\u2010MIL model has the potential to serve as a non\u2010invasive auxiliary tool for preoperative LNM prediction, offering visual interpretability regarding informative MRI slices and regions in LNM\u2010positive patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.14547","type":"journal-article","created":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T18:35:23Z","timestamp":1728239723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ranking attention multiple instance learning for lymph node metastasis prediction on multicenter cervical cancer 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