{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:34:58Z","timestamp":1778042098282,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aims to quantify and compare the dosimetric effects of varying thicknesses of StrataXRT, a silicone\u2010based gel, and other topical agents on the skin surface during volumetric modulated arc therapy (VMAT) for breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A VMAT plan was created for breast cancer treatment using a female RANDO phantom with a prescription dose of 50\u00a0Gy in 25 fractions. The planning target volume (PTV) encompassed the left breast and the regional lymph nodes. Irradiation was performed using a 6 MV photon beam. Three topical agents (StrataXRT, Hirudoid Soft Ointment, and RINDERON\u2010Vs Ointment) having eight thicknesses (0.0\u20131.5\u00a0mm) were evaluated. Dosimetry was conducted using Gafchromic EBT4 films at three anatomical locations\u2014subclavicular, medial, and lateral aspects of the left breast.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean dose enhancement ratios (DERs) of 102%\u2013116% were observed in VMAT for topical agent thicknesses of 0.1\u20130.5\u00a0mm, increasing to 116%\u2013126% at 1.0 and 1.5\u00a0mm. Among the evaluated agents, StrataXRT consistently exhibited the lowest DER, with a statistically significant difference (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated that StrataXRT exhibited the lowest DER among the evaluated topical agents in VMAT for breast cancer. Thicknesses exceeding 0.5\u00a0mm potentially exceeded the threshold dose for acute skin reactions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acm2.70070","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T07:41:21Z","timestamp":1741851681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dosimetric effect of silicone\u2010based gel on skin surface during volumetric modulated arc therapy for breast cancer"],"prefix":"10.1002","volume":"26","author":[{"given":"Tenyoh","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Radiological Sciences, Graduate School of Human Health Sciences Tokyo Metropolitan University  Arakawa\u2010ku Tokyo Japan"},{"name":"Department of Comprehensive Radiation Oncology, Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Ohira","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Graduate School of Human Health Sciences Tokyo Metropolitan University  Arakawa\u2010ku Tokyo Japan"},{"name":"Department of Comprehensive Radiation Oncology, Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mami","family":"Ogita","sequence":"additional","affiliation":[{"name":"Department of Radiology The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Radiology The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Nozawa","sequence":"additional","affiliation":[{"name":"Department of Radiology The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanari","family":"Minamitani","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Radiation Oncology, Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Radiology The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Saegusa","sequence":"additional","affiliation":[{"name":"Department of Radiology The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6850-3806","authenticated-orcid":false,"given":"Toshikazu","family":"Imae","sequence":"additional","affiliation":[{"name":"Department of Radiology The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Ueyama","sequence":"additional","affiliation":[{"name":"Department of Radiology The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuto","family":"Katano","sequence":"additional","affiliation":[{"name":"Department of Radiology The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideomi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Radiology The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weishan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Graduate School of Human Health Sciences Tokyo Metropolitan University  Arakawa\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Radiation Oncology, Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgq039"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(11)61629\u20102"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(14)60488\u20108"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compmedimag.2016.10.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014\u2010021\u201001895\u20102"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1188\/10.ONF.619\u2010626"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2023.01.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(23)00067\u20100"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101886"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.11960"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229\u20105178.142483"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019\u20105154.139874"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010023\u201007983\u20101"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.4292"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010022\u201006829\u20106"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rry078"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrad035"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0360\u20103016(97)00095\u20103"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2020.00619"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1460396922000292"},{"key":"e_1_2_9_23_1","volume-title":"Stratpharma AG","author":"Stratpahrma AG","year":"2021"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.597396"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360\u20103016(94)00423\u2010I"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.30476\/mejc.2021.86775.1372"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.13992"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/aceb48"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nima.2009.10.129"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092444"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meddos.2019.09.001"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.645328"}],"container-title":["Journal of Applied Clinical Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.70070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T20:54:31Z","timestamp":1758228871000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1002\/acm2.70070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,13]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/acm2.70070"],"URL":"https:\/\/doi.org\/10.1002\/acm2.70070","archive":["Portico"],"relation":{},"ISSN":["1526-9914","1526-9914"],"issn-type":[{"value":"1526-9914","type":"print"},{"value":"1526-9914","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,13]]},"assertion":[{"value":"2024-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70070"}}