{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:50:43Z","timestamp":1790949043592,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The 6\u2010second cone beam computed tomography (CBCT) acquisition of the Ethos HyperSight (Varian Medical Systems, Inc. Palo Alto, CA, USA) on\u2010board imaging system offers benefits, but could be too fast to accurately capture an average target position in a free\u2010breathing lung cancer patient. This study aimed to ascertain whether a 6\u2010second acquisition is appropriate for regularly breathing patients with varying respiration periods. Additionally, breathing patterns that could lead to clinically impactful inaccuracies for image\u2010guided radiation therapy (IGRT) shifts were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nine regular (sinusoidal) breathing patterns with different respiration rates (8\u201320 breaths\u2010per\u2010minute) and amplitudes, along with five irregular breathing patterns including a gasp\/cough scenario, were tested using a respiratory motion phantom with a 3\u00a0cm diameter spherical target. Once the phantom was aligned using the external chassis to remove any default shifts, the 6\u2010second CBCTs with Acuros reconstruction were acquired. Rigid registrations were performed using the 4DCT simulation average\/untagged reconstructed image as reference to align to target (simulating clinical lung IGRT setup). Sixty\u2010second CBCTs were also tested to verify the average offsets with conventional practice. The IGRT shifts were compared to 5\u00a0mm, a PTV margin typically used for lung tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Minimal (&lt;1.0\u00a0mm) shifts were observed for all regular breathing patterns with both 6\u2010second and 60\u2010second CBCT acquisitions. For moderately irregular breathing patterns and the gasp\/cough scenario, all shifts were less than 5\u00a0mm. Shifts larger than 5\u00a0mm were observed in highly irregular breathing patterns, with both 6\u2010second (14%) and 60\u2010second (24%) CBCT acquisitions. Statistical tests showed no significant differences (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &gt;\u00a00.05) between the sizes of shifts made with the two CBCT durations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 6\u2010second CBCT can effectively and reliably localize a mobile target for regular and moderately\u2010irregular breathers. Cautions should be used for highly irregular breathers, regardless of the duration of CBCT acquisition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.70130","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T10:58:14Z","timestamp":1748516294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Localization accuracy of 6\u2010second CBCT for lung IGRT with various breathing patterns"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5949-8259","authenticated-orcid":false,"given":"Jihye","family":"Koo","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8755-9218","authenticated-orcid":false,"given":"Gage","family":"Redler","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Semenenko","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Keit","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Andreozzi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(06)70904\u20104"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.11.047"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2015.10.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0360\u20103016(02)02884\u20105"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/2231\u20100762.170523"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20150687"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3397460"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.08.018"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.12850"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3567146"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/ad3cb0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2023.10.014"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2024.110458"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2024.101681"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.14299"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phro.2024.100566"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.14337"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.14311"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2024.110596"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.17325"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.66943"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2022.106670"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.84.2.202"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.84.3.286"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.04.030"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u201010\u2010474"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28477"}],"container-title":["Journal of Applied Clinical Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.70130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acm2.70130","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.70130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:01:40Z","timestamp":1772992900000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1002\/acm2.70130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,29]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/acm2.70130"],"URL":"https:\/\/doi.org\/10.1002\/acm2.70130","archive":["Portico"],"relation":{},"ISSN":["1526-9914","1526-9914"],"issn-type":[{"value":"1526-9914","type":"print"},{"value":"1526-9914","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,29]]},"assertion":[{"value":"2024-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70130"}}