{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:03:56Z","timestamp":1784282636438,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T00:00:00Z","timestamp":1752364800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["21Y11906800"],"award-info":[{"award-number":["21Y11906800"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073474"],"award-info":[{"award-number":["82073474"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Based on the combination mode of internal and external radiotherapy for cervical cancer, this study aimed to investigate an accurate transformer\u2010based deformable image registration (DIR) method for cumulative dose\u00a0assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Materials<\/jats:title>\n                    <jats:p>According to a retrospective analysis conducted on 180 patients with cervical cancer who underwent intracavitary brachytherapy (ICBT) and external beam radiation therapy (EBRT), this study proposed a mix\u2010transformer structure\u2010based deformable image registration (MTDIR) network for registering CT scans of ICBT and EBRT, followed by dose accumulation and assessment. The mean dice similarity coefficient (DSC) and Hausdorff distance (HD) of the rectum and bladder were computed to compare the performance of MTDIR with that of the state\u2010of\u2010the\u2010art VoxelMorph method and the DIR method provided by velocity. Additionally, the cumulative dose of the bladder and rectum from four methods was calculated: direct DVH parameter addition (DA), DIR\u2010based dose addition provided by Velocity (VA), VoxelMorph\u2010based dose addition (VoA), and MTDIR\u2010based dose addition (MA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean DSC values of MTDIR, VoxelMorph, and Velocity for the bladder were 0.78, 0.75, and 0.72 for the registration between CT scans of EBRT and the last ICBT, respectively. The mean DSC values of the rectum were also equal to 0.58, 0.56, and 0.52. The mean HDmean values of MTDIR, VoxelMorph, and Velocity for the bladder were 4.81, 5.16, and 5.43, and the mean HDmean values of the rectum were 5.41, 5.81, and 6.93, respectively. For the registration between CT scans of ICBT, the mean DSC values of MTDIR, VoxelMorph, and Velocity for the bladder were obtained 0.82, 0.80, and 0.77, and the mean DSC values for the rectum were equal to 0.70, 0.68, and 0.63, respectively. The mean HDmean values of MTDIR, VoxelMorph, and Velocity for the bladder were 4.22, 4.58, and 4.79, and the mean HDmean values of the rectum were obtained 4.86, 5.17, and 5.64, respectively. The results generally suggested that MTDIR outperformed VoxelMorph and\u00a0Velocity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study findings demonstrated that the model developed based on parameters obtained from the proposed method exhibited higher registration\u00a0accuracy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.70135","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T05:49:17Z","timestamp":1752472157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cumulative dose assessment with transformer\u2010based deformable image registration addition for cervical cancer patients"],"prefix":"10.1002","volume":"26","author":[{"given":"Dongdong","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai Institute of Maternal\u2010Fetal Medicine and Gynecologic Oncology Shanghai First Maternity and Infant Hospital School of Medicine Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuheng","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai Institute of Maternal\u2010Fetal Medicine and Gynecologic Oncology Shanghai First Maternity and Infant Hospital School of Medicine Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuying","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai Institute of Maternal\u2010Fetal Medicine and Gynecologic Oncology Shanghai First Maternity and Infant Hospital School of Medicine Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nantong University Xinglin College Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai Institute of Maternal\u2010Fetal Medicine and Gynecologic Oncology Shanghai First Maternity and Infant Hospital School of Medicine Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai Institute of Maternal\u2010Fetal Medicine and Gynecologic Oncology Shanghai First Maternity and Infant Hospital School of Medicine Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai Institute of Maternal\u2010Fetal Medicine and Gynecologic Oncology Shanghai First Maternity and Infant Hospital School of Medicine Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai Institute of Maternal\u2010Fetal Medicine and Gynecologic Oncology Shanghai First Maternity and Infant Hospital School of Medicine Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fubin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of School of Health Science and Engineering University of Shanghai for Science and Technology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of MedMind Technology Co., Ltd. Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of MedMind Technology Co., Ltd. Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heqing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai Institute of Maternal\u2010Fetal Medicine and Gynecologic Oncology Shanghai First Maternity and Infant Hospital School of Medicine Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai Institute of Maternal\u2010Fetal Medicine and Gynecologic Oncology Shanghai First Maternity and Infant Hospital School of Medicine Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10010093"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2014.09.010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)00288-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2018.01.001"},{"key":"e_1_2_9_7_1","first-page":"1118","article-title":"A review of the evolution of radiotherapy for cervical cancer in honor of the centennial of Peking Union Medical College Hospital","volume":"51","author":"Liu X","year":"2021","journal-title":"Rev Assoc Med Bras"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2019.08.023"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.12.015"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01667-4"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2019.1620331"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12880-017-0202-z"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrx028"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2022.09.001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.12348"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2019.2897538"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11548-023-02860-y"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2022.102615"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","unstructured":"ShiJ HeY KongY et\u00a0al.Xmorpher: Full transformer for deformable medical image registration via cross attention. 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