{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:23:13Z","timestamp":1773001393342,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to investigate the effect of inverse planning parameters on dose\u2010volume indices in brachytherapy for uterine cervical cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fourteen consecutive patients with cervical cancer who received intracavitary and interstitial brachytherapy (IC\/ISBT) were selected. Tandem, ovoid, and interstitial needles were used in all cases. The evaluation plans were recalculated from the first fraction of clinical brachytherapy plans. The correlation between the 11 dose optimization parameters of inverse planning and the 13 dose\u2010volume indices was evaluated. The parameters were adjusted in five levels, and dose optimization was performed in hybrid inverse planning optimization (HIPO). Spearman's rank correlation and multiple regression analyses were conducted to assess the association between the parameters and the indices. The indices included clinical target volume (CTV) dose, organ\u2010at\u2010risk (OAR) dose, homogeneity, and conformity. Additionally, the correlation between optimization parameters and calculation time was investigated, along with a technique for efficiently generating treatment plans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      \u201cCTV Max Weight\u201d and \u201cOAR Max Weight\u201d were the key parameters significantly affecting the indices. Increasing \u201cCTV Max Weight\u201d improved homogeneity but reduced the target coverage. The effect of \u201cOAR Max Weight\u201d on the dose reduction of CTV\n                      <jats:sub>HR<\/jats:sub>\n                      D\n                      <jats:sub>90<\/jats:sub>\n                      (\u03b2 = \u22120.59) was more significant than that on the dose reduction of OAR D\n                      <jats:sub>2cc<\/jats:sub>\n                      (\u03b2 = \u22120.21). In addition, adjusting \u201cCTV Min Weight\u201d and \u201cCTV Volume\u201d could reduce the hyper\u2010dose sleeve without increasing the OAR dose. A large number of normal tissue sampling points could negatively affect the dose distributions and increase the calculation times.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\u201cCTV Max Weight\u201d and \u201cOAR Max Weight\u201d were the most influential parameters in HIPO, significantly affecting dose\u2010volume indices in IC\/ISBT for uterine cervical cancer. Additionally, parameters that regulate the hyper\u2010dose sleeve and needle\u2010delivered dose were identified. The quality of treatment planning can be maintained and planning time reduced by appropriately optimizing these parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.70157","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T11:19:31Z","timestamp":1752491971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of treatment planning time and optimization parameters for inverse planning for intracavitary and interstitial brachytherapy in uterine cervical cancer"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8675-2953","authenticated-orcid":false,"given":"Jun","family":"Tomihara","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Graduate School of Medicine Juntendo University Bunkyo\u2010ku Tokyo Japan"},{"name":"Graduate School of Medicine Nagoya University Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9848-9251","authenticated-orcid":false,"given":"Jun","family":"Takatsu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Graduate School of Medicine Juntendo University Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Graduate School of Medicine Juntendo University Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Okonogi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Graduate School of Medicine Juntendo University Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0001-7921","authenticated-orcid":false,"given":"Tatsuya","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Graduate School of Medicine Juntendo University Bunkyo\u2010ku Tokyo Japan"},{"name":"Department of Radiology Juntendo University Urayasu Hospital Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Iijima","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Graduate School of Medicine Juntendo University Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Graduate School of Medicine Juntendo University Bunkyo\u2010ku Tokyo 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