{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:23:45Z","timestamp":1773001425078,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402393"],"award-info":[{"award-number":["82402393"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2025,7]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To explore the utility of diffusion\u2010weighted imaging (DWI)\u2010derived apparent diffusion coefficient (ADC) and exponential apparent diffusion coefficient (eADC) parameters in differentiating mega cisterna magna (MCM) from cisterna magna arachnoid cysts (CMAC).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Retrospective analysis of MRI data from 40 MCM patients, 46 CMAC patients (confirmed via clinical follow\u2010up and imaging criteria), and 36 temporal arachnoid cysts (TAC) as controls was performed. Independent sample\n t<\/jats:italic>\n \u2010tests were used to compare ADC and eADC values among the three groups.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The eADC values of MCM, CMAC, and TAC were (3.75\u00a0\u00b1\u00a00.27) \u00d7 10\n \u22122<\/jats:sup>\n , (4.53\u00a0\u00b1\u00a00.54)\u00d710\n \u22122<\/jats:sup>\n , and (4.35\u00a0\u00b1\u00a00.30) \u00d710\n \u22122<\/jats:sup>\n mm\n 2<\/jats:sup>\n \/s, respectively. There was no significant difference in the eADC value between CMAC and TAC (\n p<\/jats:italic>\n \u00a0=\u00a00.191). However, the eADC value of MCM was significantly different from the two groups (\n p<\/jats:italic>\n \u00a0=\u00a00.000). The ADC values of MCM, CMAC, and TAC were (3.30\u00a0\u00b1\u00a00.08) \u00d7 10\n \u22123<\/jats:sup>\n , (3.11\u00a0\u00b1\u00a00.12) \u00d710\n \u22123<\/jats:sup>\n , and (2.97\u00a0\u00b1\u00a00.71) \u00d7 10\n \u22123\u00a0<\/jats:sup>\n mm\n 2<\/jats:sup>\n \/s, respectively. Significant differences in ADC were observed between MCM and both CMAC and TAC (\n p<\/jats:italic>\n \u00a0=\u00a00.000\/0.003).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n DWI\u2010derived ADC and eADC parameters can effectively differentiate mega cisterna magna from cisterna magna arachnoid cysts.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acm2.70166","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T11:32:10Z","timestamp":1752492730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differentiating mega cisterna magna from cisterna magna arachnoid cysts: The diagnostic utility of quantitative diffusion\u2010weighted imaging parameters"],"prefix":"10.1002","volume":"26","author":[{"given":"Quanxiang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology TCM Hospital of Yiyuan County Yiyuan County Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Radiology Huashan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haichao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Shandong First Medical University & Shandong Province Qianfoshan Hospital Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Radiology Huashan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaping","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Shandong First Medical University & Shandong Province Qianfoshan Hospital Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Shandong First Medical University & Shandong Province Qianfoshan Hospital Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Shandong First Medical University & Shandong Province Qianfoshan Hospital Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010013\u20101269\u2010z"},{"key":"e_1_2_11_3_1","first-page":"289","article-title":"CT cisternography for presurgical evaluation of arachnoid cyst: case report","volume":"8","author":"Verhoeven S","year":"2012","journal-title":"B\u2010ENT"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.12740\/PP\/147726"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381\u2010009\u20100977\u20105"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004\u2010282\u00d720190142"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.03.008"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u20107091\u20100923\u20106_8"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.217.2.r00nv24331"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2022.12.004"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.15894"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1849094"},{"key":"e_1_2_11_13_1","volume-title":"Gray's Anatomy","author":"Gray H","year":"2011"},{"key":"e_1_2_11_14_1","volume-title":"Mega Cisterna Magna and Retrocerebellar Arachnoid Cysts. Atlas of Normal Imaging Variations of the Brain, Skull, and Craniocervical Vasculature","author":"McKinney AM","year":"2017"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.4172\/2329\u20106895.1000228"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143\u2010010\u20100262\u20109"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.189"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000002450"}],"container-title":["Journal of Applied Clinical Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.70166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acm2.70166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.70166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:00:19Z","timestamp":1772992819000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1002\/acm2.70166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/acm2.70166"],"URL":"https:\/\/doi.org\/10.1002\/acm2.70166","archive":["Portico"],"relation":{},"ISSN":["1526-9914","1526-9914"],"issn-type":[{"value":"1526-9914","type":"print"},{"value":"1526-9914","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70166"}}