{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T20:33:42Z","timestamp":1769891622913,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Precise patient\u2010specific quality assurance (PSQA) is critically important in advanced treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to evaluate the performance of the RadCalc software's electronic portal imaging device (EPID)\u2010based patient specific QA function, focusing on its ability to accurately reconstruct doses from EPID images acquired on the Elekta Harmony Pro linear accelerators (LINACs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Beam modeling was conducted for 6\u2010MV and 6\u2010MV flattening filter\u2013free (FFF) photon beams on the recently released Harmony Pro LINAC system in RadCalc. Volumetric modulated arc therapy (VMAT) plans for 6\u2010MV (19 patients) and 6\u2010MV FFF (10 patients) were generated using the ArcCHECK phantom to replicate clinical treatments. Dose calculations from RadCalc, using portal images, were compared to those generated by the treatment planning system (TPS) through gamma analysis at 1%\/1, 2%\/2, and 3%\/3\u00a0mm, with a 90% minimum passing rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For 6\u2010MV and 6\u2010MV FFF beams, gamma analysis comparing EPID data with RadCalc showed a 98.83% passing rate at 2%\/2\u00a0mm. For VMAT plans, 6\u2010MV beams achieved the highest passing rate (99.88%) for the breast case at 3%\/3\u00a0mm and the lowest (82.33%) for the lymphatic node case. Similarly, 6\u2010MV FFF beams yielded the highest passing rate (99.87%) for the abdominal case at 3%\/3\u00a0mm and the lowest (94.07%) for the bone case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RadCalc showed high accuracy for dose evaluation on the Elekta Harmony Pro LINAC. Beam modeling achieved a gamma passing rate of at least 98% (2%\/2\u00a0mm), demonstrating reliable performance even under minor setup variations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.70201","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T02:20:18Z","timestamp":1755829218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of an EPID\u2010based dose verification system for patient\u2010specific quality assurance in a harmony device"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1790-0297","authenticated-orcid":false,"given":"Dohyeon","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University, College of Medicine &amp; Heavy Ion Therapy Research Institute Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunggun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University, College of Medicine &amp; Heavy Ion Therapy Research Institute Yonsei University College of Medicine  Seoul South Korea"},{"name":"Korea Institute of Radiological and Medical Sciences  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University, College of Medicine &amp; Heavy Ion Therapy Research Institute Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soorim","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University, College of Medicine &amp; Heavy Ion Therapy Research Institute Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taeho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University, College of Medicine &amp; Heavy Ion Therapy Research Institute Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0050-0470","authenticated-orcid":false,"given":"Changhwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University, College of Medicine &amp; Heavy Ion Therapy Research Institute Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1465-5636","authenticated-orcid":false,"given":"Min Cheol","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University, College of Medicine &amp; Heavy Ion Therapy Research Institute Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University, College of Medicine &amp; 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