{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T11:05:44Z","timestamp":1771153544110,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DE033512"],"award-info":[{"award-number":["R01DE033512"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA272991"],"award-info":[{"award-number":["R01CA272991"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study investigates a prostate stereotactic body radiotherapy (SBRT) planning workflow integrating commercial artificial intelligence (AI) contouring and knowledge\u2010based planning (KBP). The purpose is to determine whether AI\u2010generated contours are comparable to physician\u2010delineated contours in achieving dosimetric goals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, 20 patients with intact prostate cancer were included. A commercial AI contouring software was applied to computed tomography (CT) scans. Contouring accuracy for the prostate, rectum, and bladder was assessed against clinical contours using geometric metrics including Dice similarity coefficient (DSC), surface DSC (sDSC), and added path length (APL).<\/jats:p>\n                    <jats:p>Volumetric modulated arc therapy plans were generated using an in\u2010house prostate SBRT KBP model without user interaction. The prescribed dose was 36.25\u00a0Gy in 5 fractions to the planning target volume with a 40\u00a0Gy simultaneous integrated boost to the prostate. All plans were calculated using AcurosXB and normalized to cover 98% of the prostate. Given the high precision required for prostate SBRT, all plans used the physician\u2010delineated (clinical) prostate contours. Three plans were generated for each patient: (1) a reference plan using clinical contours, (2) a plan using clinical prostate contour and AI organs at risk (OARs), and (3) a plan using clinical prostate contour and post\u2010processed AI OARs that removed any overlap with the clinical prostate contour. The latter two plans were recalculated on clinical contours with fixed monitor units to evaluate the dosimetric impact of AI contouring. Plan quality was evaluated using NRG\u2010GU013 criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The average DSC values were 0.83, 0.86, and 0.94 for prostate, rectum, and bladder, respectively, and the average sDSC values were 0.62, 0.81, and 0.85. AI prostate contours were clinically unacceptable. AI rectum and bladder contours overlapped the clinical prostate contour in 15 and 20 cases, respectively.<\/jats:p>\n                    <jats:p>All reference plans using clinical contours met NRG criteria. Using AI OARs or post\u2010processed AI OARs, only one case exceeded rectum V36Gy limits due to over\u2010contouring, but it became clinically acceptable after recalculation on clinical contours. Plans using post\u2010processed AI OARs yielded dosimetric results more comparable to reference plans for rectum and bladder sparing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study investigates a prostate SBRT treatment planning workflow by leveraging AI contouring and KBP. Although a fully automated workflow is not yet feasible, results are encouraging when physician\u2010delineated target volumes are combined with post\u2010processed AI contours.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.70295","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T03:26:02Z","timestamp":1759893962000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of a prostate SBRT planning workflow using auto\u2010segmentation and knowledge\u2010based planning"],"prefix":"10.1002","volume":"26","author":[{"given":"Trisha","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Emory University  Atlanta Georgia USA"},{"name":"Medical Dosimetry Program School of Health Sciences Southern Illinois University  Carbondale Illinois 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