{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:08:05Z","timestamp":1792555685746,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accurate Hounsfield units (HU) are critical for dose calculation and anatomical visualization, but are often affected by dental artifacts in head and neck (H&amp;N) cancer patients. The HyperSight cone\u2010beam computed tomography (CBCT) platform provides improved image quality over previous CBCT platforms and offers metal artifact reduction (iCBCT MAR) reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study evaluates the quality of HyperSight CBCT images compared to current clinical standards: TrueBeam CBCT for image guidance and fan\u2010beam CT (FBCT) from a CT simulator for treatment planning, using images captured during H&amp;N cancer treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Images for 30 H&amp;N cancer patients were acquired on a HyperSight CBCT, conventional TrueBeam and FBCT, with 24 patients exhibiting metal dental artifacts. The HyperSight images were reconstructed using iCBCT MAR and iterative (iCBCT Acuros) algorithms. The four image sets were rigidly registered and compared using the artifact index (AI) measured in the oral cavity and the percentile range (PR) measured in the oral cavity, brain, brainstem and eyes to assess image non\u2010uniformity. The HU accuracy was calculated relative to FBCT (baseline) for soft tissues (oral cavity, brainstem, submandibular and parotid glands), and bone (mandible). The contrast relative to baseline was evaluated between the oral cavity and nearby structures. Image\u2010based metrics were computed relative to FBCT including structural similarity index measure (SSIM), mean\u2010square error (MSE) and peak signal\u2010to\u2010noise ratio (PSNR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The HyperSight iCBCT MAR images showed a significant reduction in AI values compared to the other images (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0004), but higher PR values indicating decreased HU uniformity compared to HyperSight iCBCT Acuros and FBCT (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0002). The soft\u2010tissue HU and contrast values were significantly closer to baseline in both HyperSight images compared to TrueBeam (HU:\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001, contrast:\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). For soft\u2010tissue the HU mean absolute deviation (MAD) from baseline was 16\u00a0\u00b1\u00a010 HU for HyperSight iCBCT Acuros, 15\u00a0\u00b1\u00a010 HU for HyperSight iCBCT MAR, and 35\u00a0\u00b1\u00a022 HU for TrueBeam. For bone, the HU MAD from baseline was 153\u00a0\u00b1\u00a0233 HU, 185\u00a0\u00b1\u00a0268 HU, and 214\u00a0\u00b1\u00a0212 HU, respectively. The HyperSight iCBCT Acuros algorithm achieved significantly superior SSIM, MSE, and PSNR metrics compared to TrueBeam and HyperSight iCBCT MAR in regions with large amounts of bone and air.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HyperSight iCBCT MAR significantly reduced artifacts compared to HyperSight iCBCT Acuros, TrueBeam and FBCT, making it particularly beneficial for patients with metal implants. Both HyperSight reconstructions demonstrated improved soft\u2010tissue HU accuracy and contrast compared to TrueBeam, however the iCBCT Acuros algorithm may be preferred when metal\u2010induced artifacts are not a concern. These results support the suitability of HyperSight images in adaptive treatment workflows requiring accurate image quality, even with severe metal artifacts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.70338","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T10:00:42Z","timestamp":1764410442000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["HyperSight CBCT image quality and metal artifact reduction for adaptive head and neck radiotherapy: Results from a prospective clinical trial"],"prefix":"10.1002","volume":"26","author":[{"given":"Abby","family":"Yashayaeva","sequence":"first","affiliation":[{"name":"Department of Physics and Atmospheric Sciences Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Lee","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Department of Physics and Atmospheric Sciences Dalhousie University  Halifax Nova Scotia Canada"},{"name":"Department of Radiation Oncology, QE2 Cancer Centre Nova Scotia Health Halifax Nova Scotia Canada"},{"name":"Department of Radiation Oncology Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, QE2 Cancer Centre Nova Scotia Health Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"DeGiobbi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, QE2 Cancer Centre Nova Scotia Health Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"McMaster","sequence":"additional","affiliation":[{"name":"Department 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