{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:07:37Z","timestamp":1771337257050,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiation therapy planning (RTP) for abdominal tumors often requires multiple dose\u2010volume constraints for each organ at risk (OAR), which vary with different fractionation schemes. This variability can complicate biologically optimized treatment planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aims to extract fractionation\u2010independent dose constraints based on the concept of equivalent uniform dose (EUD), utilizing published clinical data for a range of fractionation regimens. The goal is to derive organ\u2010specific radiobiological parameters as well as the EUD for each OAR that can be used in biologically optimized treatment planning for abdominal tumors, independent of the specific fractionation scheme applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Clinical dose\u2010volume constraints\u00a0for duodenum, stomach, and small bowel were compiled from\u00a0available\u00a0literature\u00a0sources. These dose constraints were obtained for conventionally fractionated radiotherapy (CFRT), hypofractionated RT, and stereotactic body radiotherapy (SBRT) and were associated with less than a 10% risk of grade 3 toxicity as categorized by CTCAE v.3 or v.4, RTOG, and EORTC. For each OAR, an iso\u2010EUD fitting with EUD calculated based on the linear\u2010quadratic (LQ) model or linear\u2010quadratic\u2010linear (LQ\u2010L) model and a dose volume histogram generated from these dose volume constraints for each fractionation was applied to extract model parameters such as\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \/\n                      <jats:italic>\u03b2<\/jats:italic>\n                      ratio and \u2018\n                      <jats:italic>n<\/jats:italic>\n                      \u2019 (the volume effect of the OAR). Based on the obtained parameters, the dose constraint in EUD and the equivalent physical dose in 2Gy fraction (EQD2) were calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The EUD constraints for LQ\u2010L (LQ) models are 52.62 (55.10) Gy, 48.22 (48.60) Gy, and 46.10 (45.06) Gy,\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \/\n                      <jats:italic>\u03b2<\/jats:italic>\n                      values are 5.42 (5.59) Gy, 7.67 (6.76) Gy, and 12.15 (8.20) Gy, and\u00a0\u2018\n                      <jats:italic>n<\/jats:italic>\n                      \u2019\u00a0values are 0.06 (0.01), 0.03 (0.02), and 0.06 (0.08) for duodenum, small bowel, and stomach, respectively. Additional two parameters for the three OARs in LQ\u2010L are 5.15 Gy, 8.65 Gy, and 5.20 Gy for\n                      <jats:italic>dt<\/jats:italic>\n                      \u00a0and 5.40, 4.72, and 3.33 for\n                      <jats:italic>\u03b3\/\u03b1<\/jats:italic>\n                      . The LQ\u2010L model fits the clinical data better than the LQ model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The obtained\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \/\n                      <jats:italic>\u03b2<\/jats:italic>\n                      values are comparable with those published previously. The extracted EUD constraints together with the volume effect parameter \u2018\n                      <jats:italic>n<\/jats:italic>\n                      \u2019 can be used for plan optimization and evaluation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.70401","type":"journal-article","created":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T23:52:10Z","timestamp":1766965930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Organ\u2010specific equivalent uniform dose constraints and radiobiological parameters for radiation treatment planning of abdominal tumors"],"prefix":"10.1002","volume":"27","author":[{"given":"Samira","family":"Dabaghmanesh","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2260-0245","authenticated-orcid":false,"given":"X. Allen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric S.","family":"Paulson","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth","family":"Erickson","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3312-8281","authenticated-orcid":false,"given":"An","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1667\/rrav10.1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.2969065"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360\u20103016(82)90517\u2010x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360\u20103016(85)90366\u20109"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014\u2010019\u20101288\u2010y"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2014.00024"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014\u2010018\u20101040\u2010z"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/ad07f5"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.598063"},{"key":"e_1_2_10_11_1","first-page":"1100","article-title":"A generalized concept of equivalent uniform dose","volume":"26","author":"Niemerko A","year":"1999","journal-title":"Med Phys"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0360\u20103016(01)02585\u20108"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.07.1994"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.11.039"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/45\/1\/311"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.03.018"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3438081"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1120\/jacmp.v12i2.3368"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.05.071"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.09.027"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360\u20103016(91)90171\u2010y"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2015.12.002"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.05.011"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.09.022"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2020.01.012"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.983984"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.09.035"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.09.035"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.018"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2017.09.005"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.11.214"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.10.004"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0360\u20103016(02)02831\u20106"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.11.001"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2021.03.005"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053\u20104296(03)00031\u20106"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360\u20103016(95)00060\u2010C"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094859"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.06.1971"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973\u20101482.19597"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2023.109889"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.04.053"}],"container-title":["Journal of Applied Clinical Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.70401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acm2.70401","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.70401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:08:41Z","timestamp":1771333721000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1002\/acm2.70401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,28]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/acm2.70401"],"URL":"https:\/\/doi.org\/10.1002\/acm2.70401","archive":["Portico"],"relation":{},"ISSN":["1526-9914","1526-9914"],"issn-type":[{"value":"1526-9914","type":"print"},{"value":"1526-9914","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,28]]},"assertion":[{"value":"2025-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70401"}}