{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:06:52Z","timestamp":1771337212143,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This retrospective, exploratory study evaluated the dosimetric comparison and feasibility of simultaneous integrated boost (SIB) delivered with volumetric modulated arc therapy (VMAT) and helical tomotherapy (HT) in patients with locally advanced cervical cancer ineligible for brachytherapy (BRT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This exploratory study involved dosimetric treatment planning based on data from 10 patients diagnosed with locally advanced cervical cancer. SIB plans delivering 77.5\u00a0Gy to the primary tumor and 45\u00a0Gy to elective regions in 25 fractions were generated using VMAT and HT techniques. SIB plans were created using the VMAT technique in the Monaco 5.51 treatment planning system (TPS) (Elekta, Stockholm, Sweden) and the HT technique in the Precision 3.3.1 TPS (Accuray, Madison, Wisconsin, USA). Planning target volume (PTV) coverage, organ\u2010at\u2010risk (OAR) doses, and dose\u2013volume metrics of SIB plans were compared between the VMAT and HT techniques using appropriate statistical tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median PTV77.5 volume was 83.4 cc (range: 14.9\u2013218.2 cc). For PTV77.5, HT yielded a higher mean dose (79.52\u00a0Gy vs. 77.54\u00a0Gy,\u00a0\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001) and a superior conformity index (0.81\u00a0vs. 0.71,\u00a0\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001).\u00a0Bladder dose metrics were significantly lower with HT, including V53.28\u00a0Gy (5.66%\u00a0vs. 10.31%;\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.006) and D\n                      <jats:sub>2cc<\/jats:sub>\n                      (66.47\u00a0Gy vs. 70.60\u00a0Gy;\n                      <jats:italic>\u00a0p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05), while bowel V36.89\u00a0Gy volume was also reduced (94.03\u00a0cc vs. 115.13\u00a0cc;\u00a0\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.038). No statistically significant differences were observed in rectal, sigmoid, or femoral head dose parameters. Beam\u2010on time was significantly longer for HT than for VMAT (11.0\u00a0min vs. 3.4\u00a0min,\u00a0\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BRT remains the standard of care for cervical cancer. For patients ineligible for BRT, SIB is dosimetrically feasible; in this exploratory planning study, HT\u2010SIB provided better target coverage and OAR sparing than VMAT\u2010SIB. Prospective multicenter validation is necessary before wider clinical adoption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.70418","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T07:20:56Z","timestamp":1766128856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Simultaneous integrated boost in locally advanced cervical cancer patients ineligible for brachytherapy: Dosimetric comparison of VMAT versus helical tomotherapy"],"prefix":"10.1002","volume":"27","author":[{"given":"Muhammed \u0130smet","family":"Sekmen","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Akdeniz University School of Medicine  Antalya 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