{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:07:52Z","timestamp":1771337272711,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2022YFC2402305"],"award-info":[{"award-number":["2022YFC2402305"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neoadjuvant chemoradiotherapy for locally advanced rectal cancer yields pathological complete response rates of only 10%\u201320%. Dose\u2010escalation strategies may improve outcomes, but optimal GTV\u2010to\u2010PGTV margins for CT\u2010guided radiotherapy with daily IGRT remain undefined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twelve LARC patients undergoing CT\u2010guided daily IGRT with a simultaneous integrated boost were included. Daily diagnostic\u2010quality fan\u2010beam CT (FBCT) scans were acquired for IGRT. GTV and CTV were delineated on planning CT and all FBCTs. Target coverage margins were assessed by isotropically expanding the planning GTV until more than 95% of the voxels of the sequential GTVs were covered. A margin with a coverage probability threshold of 90% was defined as adequate. An independent validation cohort of 30 patients who underwent weekly FBCT\u2010guided image guidance was further analyzed. Overlap volumes between PGTVs and organs\u2010at\u2010risk (OARs; bladder and small bowel) were calculated to assess OAR sparing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Analysis of 286 FBCT scans showed that a 6\u00a0mm isotropic GTV\u2010to\u2010PGTV margin achieved&gt;95% coverage in&gt;90% of fractions. Compared with 10\u00a0mm expansion, a 6\u00a0mm PGTV reduced the overlap volumes with the bladder and small bowel by 68.5% and 68.4%, respectively. A 6\u00a0mm isotropic expansion achieved&gt;95% coverage in 91.3% of fractions in the validation cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A 6\u00a0mm isotropic GTV to PGTV margin provides adequate target coverage for most middle\u2010 and lower\u2010rectal tumors while reducing OAR overlap. This finding could facilitate safer dose escalation while maintaining target coverage. However, larger margins may be necessary for smaller tumors or those located in the high rectum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.70429","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T07:34:52Z","timestamp":1766129692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determining optimal GTV\u2010to\u2010PGTV margins for CT\u2010guided dose\u2010escalated radiotherapy with daily image guidance in locally advanced rectal cancer"],"prefix":"10.1002","volume":"27","author":[{"given":"Xi","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongguang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoqi","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai United Imaging Healthcare Co., Ltd.  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lecheng","family":"Jia","sequence":"additional","affiliation":[{"name":"Shanghai United Imaging Healthcare Co., Ltd.  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengying","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai United Imaging Healthcare Co., Ltd.  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