{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:06:35Z","timestamp":1771337195378,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Hydration of patients before the PET\/CT examination may lead to non\u2010specific FDG accumulation in the intestine. This study aims to explore the influence of isotonic saline and hypotonic water on physiologic intestinal\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG uptake in PET\/CT imaging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>185 patients were included, 82 patients were randomized to receive oral administration of isotonic saline and 103 patients received oral administration of hypotonic water before examination. About 32 patients in the isotonic group and 19 patients in hypotonic group underwent repeated PET\/CT with pre\u2010administration of hypotonic water, and the intra\u2010individual comparative analysis was performed for the first and second examinations. Segmental uptake patterns were documented and volumetric regions of interest were delineated. The SUVmax of intestinal segment and the SUVmean of liver were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant differences existed in baseline characteristics between the two groups. The isotonic group demonstrated lower physiological uptake incidence and target\u2010to\u2010background ratio (TBR) in all segments except jejunum and ascending colon (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05). Physiological uptake incidence in jejunum showed no intergroup difference, whereas the TBR of isotonic group showed lower tendency. Notably, the isotonic group exhibited higher physiological uptake incidence (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001) in the ascending colon, though no significant difference existed in TBR between two groups. These results were similar in intra\u2010individual comparative analysis of the first and second examinations. Moreover, constipation was positively associated with FDG uptake in the ileum, diarrhea was positively associated with FDG uptake in the transverse colon, ascending colon and rectum. Bone tumors and gynecological tumors were positively correlated with FDG uptake in the ascending colon and transverse colon. BMI was negatively correlated with FDG uptake in the duodenum, ileum, jejunum, and sigmoid colon.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Pre\u2010administration of isotonic saline resulted in lower physiologic\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG uptake in different intestine segments (except ascending colon), which is helpful for accurate assessment of gastrointestinal diseases.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.70431","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:44:23Z","timestamp":1767008663000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of oral hypotonic water and isotonic saline on physiological intestinal\n                    <sup>18<\/sup>\n                    F\u2010FDG uptake in PET\/CT imaging"],"prefix":"10.1002","volume":"27","author":[{"given":"Shijia","family":"Weng","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoren","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Peking University People's Hospital  Beijing 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