{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:08:05Z","timestamp":1792555685590,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Conventional cone\u2010beam computed tomography (CBCT) systems are limited by suboptimal image quality, inaccurate Hounsfield unit (HU) calibration, and reduced reliability for dose calculation. HyperSight CBCT on the Halcyon platform offers improved HU accuracy, expanded field\u2010of\u2010view (FOV), and enhanced image quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to assess the dosimetric accuracy of treatment planning using HyperSight CBCT through phantom\u2010based dose verification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included three institutions equipped with the HyperSight imaging system on the Halcyon platform, with all procedures performed after acceptance testing and calibration. Each institution generated HU\u2010to\u2010density calibration curves using computed tomography (CT) scanners and standardized phantoms, and corresponding CBCT for planning (CBCTp) scans were also acquired. Additional CBCTp scans were acquired using a consistent phantom model (062\u00a0M) across the three institutions. Reference treatment plans were created on CT images and transferred to CBCTp and CBCT datasets for dose recalculation using identical parameters. Dosimetric assessment included gamma analysis and comparisons of DVH\u2010based dosimetric metrics for relevant regions of interest (ROIs). End\u2010to\u2010end testing with an anthropomorphic phantom was performed using ion chamber measurements and film dosimetry at brain, bone, and thorax locations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HU\u2010to\u2010density curves showed consistent behavior across institutions, with larger variability only at higher densities. CBCTp calibrations agreed well with vendor references. DVH\u2010based dosimetric metrics showed differences generally within 1% for both CBCTp and CBCT when compared with CT. Across institutions, gamma analysis of both CBCTp and CBCT yielded high passing rates (\u2265 98.5% at 3%\/2\u00a0mm). End\u2010to\u2010end testing with film dosimetry showed that CBCT\u2010based plans agreed with measured doses within\u00a0\u00b1\u00a04%, while CT\u2010based plans were within\u00a0\u00b1\u00a03%. Ion chamber measurements showed all dose differences within\u00a0\u00b1\u00a02.3%, with both CBCTp and CBCT within\u00a0\u00b1\u00a01.0% of CT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HyperSight CBCT provides accurate dose calculations when properly calibrated. Phantom\u2010based validation demonstrated sub\u20102% deviations and strong agreement with CT, supporting its clinical use in adaptive radiotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.70512","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:55:04Z","timestamp":1771307704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multi\u2010institutional validation of hypersight CBCT\u2010based dose calculation on O\u2010ring linacs"],"prefix":"10.1002","volume":"27","author":[{"given":"Chih\u2010Yuan","family":"Lin","sequence":"first","affiliation":[{"name":"Varian Medical Systems A Siemens Healthineers Company  Taipei Taiwan"},{"name":"Department of Biomedical Imaging and Radiological Sciences National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Medical Physics and Radiation Measurements Laboratory National Yang Ming Chiao Tung University 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