{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:05:54Z","timestamp":1792080354740,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accurate in vivo dosimetry is crucial for dose monitoring of cardiac implantable electronic devices (CIED) and for dose verification for special procedures such as total body irradiation (TBI) and total skin electron therapy (TSET).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>A new near real\u2010time in vivo dosimetry system using radiochromic films (RCF) is investigated for clinical use in megavoltage external beam radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Pnt\u2010Dos\u2122 in vivo dosimetry system comprises of a new type of RCF and a dedicated software module. Each Pnt\u2010Dos device is a small piece of RCF individually packed with a unique QR code for identification and record keeping. Different from the traditional film dosimetry workflow, where a film developing time of at least 16\u00a0hours is recommended, a near real\u2010time dose readout can be achieved with the Pnt\u2010Dos system using a novel calibration procedure. This involves an automated scanning process at user\u2010specified time intervals, utilizing auto\u2010region of interest (ROI) detection and triple\u2010channel calibration to capture the time\u2010resolved post\u2010irradiation growth. Two standard Epson scanner models (V600\/13000XL) were used to cross\u2010validate readouts and accommodate users who may prefer to utilize existing 13000XL scanners rather than acquire an additional V600 for in vivo dosimetry. The dosimetric accuracy was evaluated over a range of 15\u2013400 cGy. Angular dependence was studied in 45\u00b0 increments over 360\u00b0, normalized to the response at 0\u00b0, at 250 cGy using a cylindrical phantom. Energy dependence was evaluated for four photon energies (6 MV, 6 MV FFF, 10 MV FFF, 15 MV) and five electron energies (6 MeV, 9 MeV, 12 MeV, 16 MeV, and 20 MeV). Long\u2010term reproducibility\/stability were assessed with nine devices with different doses under identical conditions, alongside daily scans of quality control (QC) devices over three months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The system provides accurate dose measurements across high\u2010 and low\u2010dose ranges. All readings were within specification: accuracy was\u00a0&lt;\u00a0\u00b1\u00a05 cGy for doses \u2264 80 cGy doses (max discrepancy 6.0 cGy), and\u00a0&lt;\u00a0\u00b1\u00a05% for doses\u00a0&gt;\u00a080 cGy on average (max discrepancy 5.1%). Angular dependence showed a maximum variation of 2.6%\u00a0\u00b1\u00a02.1% when the beam passed through the posterior oblique side of the device. Daily QC\/reproducibility tests confirmed system constancy of 0.1% average day\u2010to\u2010day variation. Energy dependence analysis revealed deviations of up to 4.9%\u00a0\u00b1\u00a02.3% for all photon and electron energies compared to 6 MV photons, indicating the need for energy correction during commissioning. Film readings were compared with ion chamber measurements at 10 \u00d7 10\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      , d\n                      <jats:sub>max<\/jats:sub>\n                      , 100\u00a0cm SAD (photons) or 100\u00a0cm SSD (electrons). Both scanners provided comparable readouts, within 1.3 cGy for doses \u2264 80 cGy and 0.6% for doses\u00a0&gt;\u00a080 cGy. Based on these findings, user guidelines were established to ensure optimal performance and accuracy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The new film\u2010based in vivo dosimetry system provides an automated workflow that enables consistent, time\u2010independent, and near real\u2010time readout with a user\u2010friendly design that simplifies handling and analysis, thereby streamlining in vivo dosimetry measurements. It also provides a traceable record of the patient dosimetry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.70525","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:42:10Z","timestamp":1773002530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Commissioning of a near real\u2010time in vivo film dosimetry system"],"prefix":"10.1002","volume":"27","author":[{"given":"Yunjie","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Medical Physics Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4054-8789","authenticated-orcid":false,"given":"Seng Boh","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4094-0892","authenticated-orcid":false,"given":"Indra","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1142-7419","authenticated-orcid":false,"given":"Jeonghoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Memorial Sloan Kettering Cancer Center  New York New York 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