{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:42:14Z","timestamp":1793032934787,"version":"4.5.0"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2026,5]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Seroma formation after breast\u2010conserving surgery is a common postoperative occurrence that can significantly affect the accuracy of radiation therapy. Variations in seroma size and shape during treatment introduce uncertainties in dose delivery, potentially compromising target coverage and increasing exposure to healthy tissue. Conventional monitoring relies on periodic imaging such as CT or MRI, which may not capture dynamic changes during the treatment course.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n This technical note investigates the feasibility of using Cherenkov imaging for real\u2010time monitoring of seroma evolution during breast cancer radiotherapy. The goal is to determine whether this approach can provide actionable information to improve treatment accuracy and support adaptive planning.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Breast cancer patients undergoing whole\u2010breast irradiation were treated using a TrueBeam linear accelerator (Varian, Palo Alto, CA) with surface guided radiation therapy (SGRT) for positioning and breath\u2010hold gating. Seromas were initially contoured during treatment planning and reassessed mid\u2010treatment using cone\u2010beam CT. Cherenkov imaging (DoseRT, VisionRT) was integrated into daily treatment sessions to visualize seroma changes in real time. Seroma size and shape were recorded for each fraction and compared with initial planning volumes and mid\u2010treatment imaging.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Cherenkov imaging successfully identified and tracked seroma changes throughout the treatment course. Significant variability was observed among patients: some exhibited progressive enlargement, while others demonstrated resolution. For example, one patient's seroma increased from 24 cm\n 3<\/jats:sup>\n at planning to 29 cm\n 3<\/jats:sup>\n at completion, whereas another decreased from 12.5 to 5.8 cm\n 3<\/jats:sup>\n . Pixel\u2010based measurements from Cherenkov imaging correlated with volumetric changes observed on CT, confirming the reliability of this technique. These findings underscore the dynamic nature of seromas and the potential need for adaptive interventions during treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Cherenkov imaging offers a practical, noninvasive solution for real\u2010time monitoring of seroma changes during breast cancer radiotherapy. By providing immediate feedback on anatomical variations, this technology can enhance treatment accuracy, reduce unnecessary radiation exposure to healthy tissues, and inform adaptive planning strategies. Further research is warranted to evaluate clinical outcomes, workflow integration, and cost\u2010effectiveness.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acm2.70553","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T02:54:56Z","timestamp":1778468096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010time monitoring of seroma changes during breast cancer radiotherapy using Cherenkov imaging: A technical note"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3905-6314","authenticated-orcid":false,"given":"Michael","family":"Tallhamer","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology AdventHealth Parker Parker Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0475-2926","authenticated-orcid":false,"given":"Adi","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology AdventHealth Celebration Celebration Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(11)61629\u20102"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524\u20104741.2003.09504.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.10.037"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2011.29.4.277"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.07.699"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1274082"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.11.013"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2025.09.004"},{"key":"e_1_2_11_10_1","first-page":"451","article-title":"Visible emission of clean liquids by action of gamma radiation","volume":"2","author":"Cherenkov P.","year":"1934","journal-title":"Doklady Akademil Mauk SSE"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/60\/1\/L1"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.01.046"}],"container-title":["Journal of Applied Clinical Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.70553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acm2.70553","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.70553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:29:45Z","timestamp":1793032185000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1002\/acm2.70553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/acm2.70553"],"URL":"https:\/\/doi.org\/10.1002\/acm2.70553","archive":["Portico"],"relation":{},"ISSN":["1526-9914","1526-9914"],"issn-type":[{"value":"1526-9914","type":"print"},{"value":"1526-9914","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70553"}}