{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:01:55Z","timestamp":1789740115266,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Clinical implementation of lattice radiotherapy (LRT) remains constrained by the absence of standardized, automated tools for comprehensive post\u2010plan dosimetric analysis within commercial treatment planning systems (TPS). Herein, an automated script\u2010based tool was developed using the Eclipse Scripting API (ESAPI) to enable rapid, standardized calculation of key LRT\u2010specific metrics, including peak\u2010to\u2010valley dose ratio (PVDR), equivalent uniform dose (EUD), and ablative dose ratio (ADR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A modular computational architecture comprising four functional layers was implemented: (1) user interface for protocol configuration, (2) computation layer integrating multiple PVDR algorithms, (3) data service layer providing direct read\u2010only access to three\u2010dimensional dose and anatomical data via ESAPI, and (4) reporting module. To accommodate ESAPI security restrictions, a dual\u2010script architecture incorporating a preprocessing sphere segmentation module was established. Validation was performed using a retrospective cohort of 12 lung cancer LRT patients, with accuracy assessed against manual TPS measurements and established reference values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Concordance between automated and manual TPS measurements was high. Standard dose\u2010volume parameter extraction exhibited perfect agreement. For spatially explicit PVDR analysis, mean absolute error relative to manual profile assessment was 0.034 (absolute VPDR units). EUD calculations deviated less than 3% from published reference data. Evaluation time per plan was reduced from 15.41\u00a0\u00b1\u00a03.20\u00a0min (manual) to 1.97\u00a0\u00b1\u00a00.34\u00a0min (automated), representing a 7.8\u2010fold efficiency gain with elimination of inter\u2010operator variability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This ESAPI\u2010based tool automates and standardizes dosimetric evaluation of LRT, addressing a practical workflow bottleneck. Integration of multiple calculation methods within a deterministic framework establishes a shareable benchmark for consistent multi\u2010institutional analysis, providing a foundation for future investigations correlating detailed dosimetric parameters with clinical outcomes in spatially fractionated radiotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.70700","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:09:32Z","timestamp":1785164972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and validation of an automated evaluation system for lattice radiotherapy using a commercial treatment planning system scripting API"],"prefix":"10.1002","volume":"27","author":[{"given":"Xingliu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The Second Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology School of Medicine Shanghai Pulmonary Hospital Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Shanghai Proton and Heavy Ion Center Fudan University Cancer Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology School of Medicine Shanghai Pulmonary Hospital Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2019.10.004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1667\/RADE\u201020\u201000066.1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.03.028"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4274\/balkanmedj.galenos.2025.2025\u20102\u2010129"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.4263"},{"key":"e_1_2_11_7_1","volume-title":"Varian Medical Systems. Eclipse Photon and Electron Reference Guide","year":"2020"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2025.06.3901"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1667\/RADE\u201020\u201000047.1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.16761"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.14469"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2024.103408"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2307\/2412323"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2022.03.005"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2024.104490"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2024.104823"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phro.2024.100549"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.14489"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.01.073"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2021.100866"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174267"}],"container-title":["Journal of Applied Clinical Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.70700","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acm2.70700","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acm2.70700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:07:10Z","timestamp":1789736830000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1002\/acm2.70700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/acm2.70700"],"URL":"https:\/\/doi.org\/10.1002\/acm2.70700","archive":["Portico"],"relation":{},"ISSN":["1526-9914","1526-9914"],"issn-type":[{"value":"1526-9914","type":"print"},{"value":"1526-9914","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]},"assertion":[{"value":"2026-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70700"}}