{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:02:04Z","timestamp":1789700524967,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>TG\u201043 formalism dose calculation for brachytherapy with the homogeneous water\u2010based assumption is widely used, which can lead to dose inaccuracy in treatment planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Extremity malignancies are also treated with high\u2010dose\u2010rate (HDR)\n                      <jats:sup>192<\/jats:sup>\n                      Ir interstitial brachytherapy, a treatment site that has not been specifically investigated in prior comparative dosimetric studies, and the proximity of source dwell positions to bone and air introduces significant heterogeneity. BrachyPlanCheck, an in\u2010house brachytherapy second dose verification program for Monte Carlo (MC) simulations, incorporates these heterogeneities and is used for a comparative dosimetric study on extremity malignancies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>BrachyPlanCheck was commissioned and validated in both a homogeneous water phantom and a heterogeneous breast phantom. The clinical evaluation included 8 patient\u2010specific lower limb brachytherapy plans, comparing TG\u201043 and MC calculation using BrachyPlanCheck. Dosimetric differences were evaluated using dose comparisons, gamma index analysis, and dose\u2010volume histogram (DVH) metrics for clinical target volume (CTV) and organ\u2010at\u2010risk (OAR), including bone and skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In commissioning Level 1, MC simulations using BrachyPlanCheck demonstrated point dose agreement within\u00a0\u00b1\u00a00.9%. Gamma passing rates exceeded 99.9% with criteria 1\u00a0mm\/1% in commissioning Level 2. In clinical evaluation, TG\u201043 calculation overestimated CTV V150 by up to 10.50% and CTV D90 by up to 7.25%. OAR doses were generally higher with TG\u201043, with mean differences of 1.09% for bone D1cc (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0\u00a00.109), 1.38% for bone D0.1cc (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0\u00a00.078), 7.30% for skin D2cc (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0\u00a00.008), and 5.68% for skin D0.1cc (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0\u00a00.008).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Validated by phantom and patient study, BrachyPlanCheck demonstrated robust performance for independent secondary dose verification. TG\u201043 calculation overestimated dose to CTV and OAR in extremity malignancy cases compared with BrachyPlanCheck.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.70778","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:42:56Z","timestamp":1787978576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Monte Carlo based dose verification tool for an HDR Ir\u2010192 brachytherapy source and its evaluation on extremity malignancies"],"prefix":"10.1002","volume":"27","author":[{"given":"Peixiong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Medical Physics Hong Kong Sanatorium &amp; Hospital  Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Wah","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Hong Kong Sanatorium &amp; Hospital  Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rihui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Physics Graduate Program Duke Kunshan University  Kunshan Jiangsu P.R. 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