{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:02:11Z","timestamp":1789700531199,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Applied Clin Med Phys"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cone\u2010beam computed tomography (CBCT) is increasingly used in adaptive radiotherapy (ART), yet the dosimetric accuracy and image quality of advanced CBCT imaging platforms\u2014such as Halcyon HyperSight 4.0 (HH), which combines an upgraded detector panel with advanced iterative reconstruction, scatter\u2010correction, and metal\u2010artifact\u2010reduction algorithms\u2014remain insufficiently characterized clinically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate HH CBCT reconstruction algorithms for ART by assessing image quality, dose accuracy, and in vivo verification using optically stimulated luminescence dosimeters (OSLDs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Task\u2010based image quality was evaluated with ImQuest per AAPM TG\u2010233 using a Gammex 464 ACR phantom on three systems: Canon Aquilion Large Bore CT (LB, reference), TrueBeam (TB), and HH. Seven algorithms were compared (LB, TB\u2010FDK, TB\u2010iCBCT, HH\u2010FDK, HH\u2010iCBCT, HH\u2010Acuros, HH\u2010MAR), with d\u2032 (the detectability index, a task\u2010based image\u2010quality metric per AAPM TG\u2010233) derived for four insert materials (polyethylene, acrylic, bone, air). A volumetric modulated arc therapy (VMAT) plan was independently re\u2010optimized (using identical optimization objectives\/constraints as the LB reference plan) on HH\u2010iCBCT, HH\u2010Acuros, and HH\u2010MAR images and verified by portal dosimetry (1%\/1\u00a0mm gamma), delivered to an Alderson RANDO phantom with dose measured at 15 points (2 clinical target volume [CTV], 7 organ\u2010at\u2010risk [OAR], and 6 lung points) using BeO OSLDs and compared to LB (\u00b1\u00a05% criterion). Mean\n                      <jats:italic>d<\/jats:italic>\n                      \u2032 per algorithm was compared to LB via one\u2010sample\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HH\u2010iCBCT (\n                      <jats:italic>d<\/jats:italic>\n                      \u2032\u00a0=\u00a04.70,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.016), HH\u2010Acuros (\n                      <jats:italic>d<\/jats:italic>\n                      \u2032\u00a0=\u00a04.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005), and HH\u2010MAR (\n                      <jats:italic>d<\/jats:italic>\n                      \u2032\u00a0=\u00a04.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.024, numerically highest) showed significant detectability improvement over LB (\n                      <jats:italic>d<\/jats:italic>\n                      \u2032\u00a0=\u00a04.42), with HH\u2010iCBCT most consistent across materials. Mean absolute OSLD dose errors were 1.71%, 2.09%, and 2.90%; all 15 points met the\u00a0\u00b1\u00a05% criterion except Lt_lung2 in HH\u2010MAR (\u22125.32%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HH\u2010iCBCT demonstrated clinically acceptable image quality and dose accuracy for CBCT\u2010based ART, supported by in vivo BeO OSLD verification in an anthropomorphic phantom.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acm2.70782","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:40:50Z","timestamp":1787978450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Task\u2010based image quality and dosimetric validation of HyperSight CBCT for adaptive 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7305-3280","authenticated-orcid":false,"given":"Kwan\u2010Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Program in Biomedical Science, Graduate School Korea University  Sejong Republic of Korea"},{"name":"Division of Semiconductor Physics Korea University  Sejong Republic of Korea"},{"name":"Department of Applied Physics, Graduate School Korea University  Sejong Republic of 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