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Data from participants with BD<\/jats:styled-content>\u2010MRI<\/jats:styled-content> were compared with those from participants with predominant white matter lesions (WML<\/jats:styled-content>\u2010MRI<\/jats:styled-content>), scattered multiple lacunes (ML<\/jats:styled-content>\u2010MRI<\/jats:styled-content>), or normal MRI<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Results<\/jats:title>Fourteen BD<\/jats:styled-content>\u2010MRI<\/jats:styled-content> patients (2.8%) were detected at baseline. The mean MMSE<\/jats:styled-content> scores in the BD<\/jats:styled-content>\u2010MRI<\/jats:styled-content>, WML<\/jats:styled-content>\u2010MRI<\/jats:styled-content>, ML<\/jats:styled-content>\u2010MRI<\/jats:styled-content>, and normal MRI<\/jats:styled-content>s groups were 26.4, 28.2, 28.4, and 28.5, respectively, and the mean UPDRSM<\/jats:styled-content> scores were 9.1, 1.3, 3.1, and 1.7, respectively. At the 30\u2010month follow\u2010up, mortality rates in the normal MRI<\/jats:styled-content>s, WML<\/jats:styled-content>\u2010MRI<\/jats:styled-content> and ML<\/jats:styled-content>\u2010MRI<\/jats:styled-content> were 4%, 9.1%, and 22.2%, respectively, and follow\u2010up MRI<\/jats:styled-content>s were available for 80%, 82%, and 61% of the participants, respectively. In the BD<\/jats:styled-content>\u2010MRI<\/jats:styled-content>, however, five patients were deceased, and only five follow\u2010up individual MRI<\/jats:styled-content>s were available (33.3%). Autopsies were performed on six of eight BD<\/jats:styled-content>\u2010MRI<\/jats:styled-content> brains, and these brains fulfilled the pathological criteria for BD<\/jats:styled-content> independent of Alzheimer disease pathology. All these six individuals also showed systemic atherosclerosis and renal arterio\u2010arteriolosclerosis.<\/jats:p><\/jats:sec>Interpretation<\/jats:title>The BD<\/jats:styled-content>\u2010MRI<\/jats:styled-content> participants had poor prognoses and showed pure BD<\/jats:styled-content> pathology with advanced systemic vascular disease. BD<\/jats:styled-content>\u2010MRI<\/jats:styled-content> appears to be a predictor of vascular neurocognitive impairment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.123","type":"journal-article","created":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T06:53:24Z","timestamp":1412578404000},"page":"813-821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["MRI<\/scp> features of Binswanger's disease predict prognosis and associated pathology"],"prefix":"10.1002","volume":"1","author":[{"given":"Ichiro","family":"Akiguchi","sequence":"first","affiliation":[{"name":"Center of Neurological and Cerebrovascular Diseases Takeda Hospital Kyoto Japan"},{"name":"Department of Health Science Kyoto Koka Women's University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Budka","sequence":"additional","affiliation":[{"name":"Institute of Neurology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitomo","family":"Shirakashi","sequence":"additional","affiliation":[{"name":"Center of Neurological and Cerebrovascular Diseases Takeda Hospital Kyoto Japan"},{"name":"Biomedical MR Science Center Shiga University of Medical Science Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelheid","family":"Woehrer","sequence":"additional","affiliation":[{"name":"Institute of Neurology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Health Science Kyoto Koka Women's University Kyoto Japan"},{"name":"Biomedical MR Science Center Shiga University of Medical Science Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Shiino","sequence":"additional","affiliation":[{"name":"Biomedical MR Science Center Shiga University of Medical Science Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumasa","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyoto Katsura Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Department of Health Science Kyoto Koka Women's University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Krampla","sequence":"additional","affiliation":[{"name":"Department of Radiology Danube Hospital Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Jungwirth","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute of Aging Research Danube Hospital Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Fischer","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute of Aging Research Danube Hospital Vienna Austria"},{"name":"Department of Psychiatry Danube Hospital Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,6]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"91","article-title":"Diagnosis and management of vascular cognitive impairment and dementia","volume":"63","author":"Erkinjuntti T","year":"2002","journal-title":"J Neural Transm Suppl"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820db666"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820eb127"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0944-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.53.11.961"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.4.626"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00190-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.7.1423"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/str.33.1.297"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6139-5_11"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.10.1285"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000104478"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.3.359"},{"issue":"1","key":"e_1_2_8_15_1","first-page":"23","article-title":"Do specific MRI features of Binswanger's disease also reveal cognitive\/motor impairments and the corresponding neuropathology? 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