{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:43:12Z","timestamp":1792500192093,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T00:00:00Z","timestamp":1428710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health - NINDS","doi-asserted-by":"crossref","award":["NS-R37-31146"],"award-info":[{"award-number":["NS-R37-31146"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004752","name":"Victorian Government","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Operational Infrastructure Support Grant"},{"name":"Victorian Life Sciences Computation Initiative (VLSCI)","award":["VR0056"],"award-info":[{"award-number":["VR0056"]}]},{"name":"University of Melbourne Research Scholarship"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Childhood absence epilepsy (<jats:styled-content style=\"fixed-case\">CAE<\/jats:styled-content>) is a childhood\u2010onset generalized epilepsy. Recent <jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content> studies have suggested that frontal cortex activity occurs before thalamic involvement in epileptic discharges suggesting that frontal cortex may play an important role in childhood absence seizures. Neurocognitive deficits can persist after resolution of the epilepsy. We investigate whether structural connectivity changes are present in the brains of <jats:styled-content style=\"fixed-case\">CAE<\/jats:styled-content> patients in young adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cortical thickness measurements were obtained for 30 subjects with <jats:styled-content style=\"fixed-case\">CAE<\/jats:styled-content> (mean age 21\u00a0\u00b1\u00a02\u00a0years) and 56 healthy controls (mean age 24\u00a0\u00b1\u00a04) and regressed for age, sex, and total intracranial volume (<jats:styled-content style=\"fixed-case\">TIV<\/jats:styled-content>). Structural connectivity was evaluated by measuring the correlation between average cortical thicknesses in 915 regions over the brain. Maps of connectivity strength were then obtained for both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When compared to controls, the <jats:styled-content style=\"fixed-case\">CAE<\/jats:styled-content> group shows overall increased \u201cconnectivity\u201d with focal increased connection strength in anterior regions including; the anterior cingulate and the insula and superior temporal gyrus bilaterally; the right orbito\u2010frontal and supramarginal regions; and the left entorhinal cortex. Decreased connection strength in the <jats:styled-content style=\"fixed-case\">CAE<\/jats:styled-content> group was found in the left occipital lobe, with a similar trend in right occipital lobe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Brains in young adults whose <jats:styled-content style=\"fixed-case\">CAE<\/jats:styled-content> was resolved had abnormal structural connectivity. Our findings suggest that frontal regions correlate most with cortical thickness throughout the brain in <jats:styled-content style=\"fixed-case\">CAE<\/jats:styled-content> patients, whereas occipital regions correlate most in well matched normal controls. We interpret this as evidence of a developmental difference in <jats:styled-content style=\"fixed-case\">CAE<\/jats:styled-content> that emphasizes these frontal lobe regions, perhaps driven by frontal lobe epileptiform activity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.178","type":"journal-article","created":{"date-parts":[[2015,4,12]],"date-time":"2015-04-12T04:23:31Z","timestamp":1428812611000},"page":"456-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Abnormal cortical thickness connectivity persists in childhood absence epilepsy"],"prefix":"10.1002","volume":"2","author":[{"given":"Evan K.","family":"Curwood","sequence":"first","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health Austin Campus Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangor","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Florey Department of Neuroscience and Mental Health The University of Melbourne Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Carney","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health Austin Campus Heidelberg Victoria Australia"},{"name":"Department of Medicine The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne T.","family":"Berg","sequence":"additional","affiliation":[{"name":"Epilepsy Center Ann and Robert H. Lurie Children's Hospital of Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Abbott","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health Austin Campus Heidelberg Victoria Australia"},{"name":"Florey Department of Neuroscience and Mental Health The University of Melbourne Heidelberg Victoria Australia"},{"name":"Department of Medicine The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme D.","family":"Jackson","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health Austin Campus Heidelberg Victoria Australia"},{"name":"Florey Department of Neuroscience and Mental Health The University of Melbourne Heidelberg Victoria Australia"},{"name":"Department of Medicine The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1989.tb05316.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01680.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a9f3ca"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03119.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02522.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S1053-8119(03)00294-5","article-title":"fMRI \u201cdeactivation\u201d of the posterior cingulate during generalized spike and wave","volume":"20","author":"Archer JS","year":"2003","journal-title":"Neuroimage"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504935102"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01626.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f11c06"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821e54de"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824f801d"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.03.036"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00435.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.05.007"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02198.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20944"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2575"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060159"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.054"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.04.261"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.01.055"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb00738.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb00739.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp187"},{"key":"e_1_2_8_27_1","volume-title":"Epileptic syndromes in infancy, childhood, and adolescence","author":"Roger J","year":"1992"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12862"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0396"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.003"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.042"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0030017"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/30918"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002051"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.02.001"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq291"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22120"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5062-08.2009"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308091110"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.090504197"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01952.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21045"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2011.07.014"},{"key":"e_1_2_8_46_1","first-page":"77","volume-title":"Progress in brain research","author":"Jernigan TL","year":"2011"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.08.003"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5309-07.2008"},{"key":"e_1_2_8_49_1","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.1523\/JNEUROSCI.21-13-04789.2001","article-title":"Neuronal hypertrophy in the neocortex of patients with\u00a0temporal\u00a0lobe epilepsy","volume":"21","author":"Bothwell S","year":"2001","journal-title":"J Neurosci"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.03.008"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2012.11.008"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.06.034"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facn3.178","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.178","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.178","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T04:51:56Z","timestamp":1696395116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,11]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1002\/acn3.178"],"URL":"https:\/\/doi.org\/10.1002\/acn3.178","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,11]]},"assertion":[{"value":"2014-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}