{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T17:50:00Z","timestamp":1769104200897,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T00:00:00Z","timestamp":1426118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Stroke research and clinical trials have focused mainly on anterior circulation stroke (<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>). Since clinical characteristics, mechanisms, and outcomes of posterior circulation stroke (<jats:styled-content style=\"fixed-case\">PCS<\/jats:styled-content>) have been reported different from <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>, more <jats:styled-content style=\"fixed-case\">PCS<\/jats:styled-content> studies are required, particularly researching the etiologies, to help establish an optimal management strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study analyzed patients of <jats:styled-content style=\"fixed-case\">PCS<\/jats:styled-content> who were consecutively admitted and registered in Taipei Veterans General Hospital Stroke Registry between 1 January 2012 to 28 February 2014. We demonstrated the distribution of etiologies, compared the clinical characteristics\/outcomes among different etiology groups, and used univariate\/multivariate analyses to identify the predictors for poor functional outcome (modified Rankin Scale \u22655) at discharge and 3\u00a0month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 286 patients of <jats:styled-content style=\"fixed-case\">PCS<\/jats:styled-content> were included for analyses. Basilar artery atheromatous branch occlusive disease (<jats:styled-content style=\"fixed-case\">BABO<\/jats:styled-content>, 28.0%) and large artery dissection (25.9%) were the two most common etiologies, followed by large artery atherosclerotic stenosis\/occlusion (<jats:styled-content style=\"fixed-case\">LAA<\/jats:styled-content>, 20.6%), cardioembolism (<jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>, 18.5%) and small vessel disease (7.0%). Age, vascular risk factors, infarct locations and patterns, and outcomes were different among these five etiology groups. Multivariate analyses showed that age &gt;70\u00a0y\/o (discharge\/3\u00a0month, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 3.05, 1.23\u20137.56\/8.39, 2.32\u201330.33), admission <jats:styled-content style=\"fixed-case\">NIH<\/jats:styled-content> Stroke Scale &gt;9 (19.50, 8.69\u201343.75\/13.45, 5.59\u201332.39), and etiology (<jats:styled-content style=\"fixed-case\">LAA<\/jats:styled-content> versus <jats:styled-content style=\"fixed-case\">BABO<\/jats:styled-content>: 5.00, 1.58\u201315.83\/4.00, 1.19\u201313.4; <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> versus <jats:styled-content style=\"fixed-case\">BABO<\/jats:styled-content>: 3.36, 1.02\u201311.09\/4.66, 1.40\u201315.46) were independently associated with poor functional outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The etiologies of <jats:styled-content style=\"fixed-case\">PCS<\/jats:styled-content> are heterogeneous and shown to be associated with functional outcomes. Our results have shed lights on future pathophysiological research and designs of clinical trials for <jats:styled-content style=\"fixed-case\">PCS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.188","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T13:01:18Z","timestamp":1426165278000},"page":"510-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Stroke etiology is associated with outcome in posterior circulation stroke"],"prefix":"10.1002","volume":"2","author":[{"given":"Chih\u2010Ping","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Neurology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"National Yang Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin\u2010Sern","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Neurology Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng\u2010Chi","family":"Chang","sequence":"additional","affiliation":[{"name":"National Yang Ming University Taipei Taiwan"},{"name":"Department of Radiology Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Yung","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Neurology Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Chi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"National Taipei University of Nursing and Health Sciences Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jui\u2010Yao","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Neurology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"National Taipei University of Nursing and Health Sciences Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung\u2010Yi","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Neurology Tungs' Taichung Metro Harbor Hospital School of Medicine Chung Shan Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Hwa","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"National Yang Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.9.1083"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70211-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g3175"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.658500"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.21.9.900"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000150543.61244.06"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.583534"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20204"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2005.1.1.14"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.6.868"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.6.880"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103223441206"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.936526"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70299-5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60151-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.8.2011"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg197"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp026"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.553859"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016042"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01274.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.211151"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02709.x"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facn3.188","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.188","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T04:51:45Z","timestamp":1696395105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,12]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1002\/acn3.188"],"URL":"https:\/\/doi.org\/10.1002\/acn3.188","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,12]]},"assertion":[{"value":"2014-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}